114 
The Minute Anatomy of Two Cases of Cancer. 
nuclei escaped abundantly into the “ juice ” in a quite naked con- 
dition. Very often, however, some of the nuclei appeared in the 
“juice ” thus obtained surrounded by a more or less irregular mass 
of protoplasm, resembling thus “ the typical cancer cells ” of the 
older writers. 
The nucleated cylinders usually varied from the ToVoth f° the 
Troijth of an inch in diameter, but in some parts attained still greater 
dimensions. In places where the section passed transversely through 
the cylinders they appeared as round or somewhat oval masses of 
protoplasm, stuffed with nuclei, which might readily pass for the 
“ mother-cells ” of the books. In glycerine and balsam preparations 
the protoplasm of the cylinders was often shrunk away from the 
connective-tissue stroma, the margin of which being clear and trans- 
parent might almost be taken for a limiting membrane. 
The nuclei of the cylinders were transparent or but slightly 
granular when fresh, and usually contained a single large nucleo- 
lus. In the balsam-mounted sections they appeared more decidedly 
granular. Elongated nuclei with two nucleoli and other indications 
of commencing division were but rarely observed. The nuclei of 
the connective-tissue stroma were generally rather longer than those 
of the cylinders, but much narrower. Occasionally their position 
was occupied by little rows of two, four, or more nuclei, which 
might be supposed to be the progeny of the connective-tissue nuclei. 
Such rows were generally surrounded by a small quantity of pro- 
toplasm. 
Sections taken from the peripheral portions of the tumour gene- 
rally presented a certain amount of more or less altered adipose 
tissue. The quantity of the matrix between the fat-cells was much 
increased, so that instead of the individual cells of each fat-lobule 
being apparently in contact, they were separated to a greater or less 
extent (often the aoWfh of an inch or more), by a delicately- fibril- 
lated matrix, in which were imbedded many oval nuclei which were 
both larger and more numerous than normal. The connective- 
tissue septae between the individual fat-lobules were also greatly 
thickened, and in many places contained cell cylinders quite like 
those of the body growth. (See Microscopical Section, Nos. 4615 
to 4631.) 
No. 958, Medical Section. A portion of the right lobe of the liver. 
The liver was nearly normal in size, but presented on section nume- 
rous little hard whitish nodules, varying from the size of a pin-head 
to that of a pea, or even smaller. These were invariably situated in 
the course of the portal vessels, i. e. in the interlobular spaces. In 
structure they closely approximated the scirrhous tissue of the breast 
tumour as above described, simply the meshes of the plexus of nu- 
cleated cylinders were less elongated, and in the sections, therefore, 
