The Minute Anatomy of Two Cases of Cancer. 115 
these more frequently appeared as round or oval forms (the cylinders 
having been cut more or less obliquely), and less frequently as con- 
tinuous cylinders of some length, such as were common in the breast 
sections. Hence, on superficial observation the sections of these 
cancer nodules of the liver appeared at first sight as a nucleated 
connective-tissue stroma, in which numerous large, round, oval, or 
elliptical mother-cells, containing numerous nuclei, were imbedded. 
On carefully focussing, however, it was easy to perceive that these 
apparently separate masses of protoplasm formed in fact portions of 
a complete network of nucleated cylinders, which had been divided 
by the section. As in the case of the mammary tumour, the 
cylinders appeared to consist of a mass of granular protoplasm with 
numerous nuclei imbedded, actual cell walls being nowhere distin- 
guishable. 
Nowhere did it appear that the hepatic cells had contributed by 
their multiplication to the formation of the cancer nodules ; on the 
contrary, the actual structure seemed quite clearly to contradict any 
such inference. For some little distance around each little cancer 
nodule the cut end of single nucleated cylinders were frequently 
observed imbedded in the very substance of the hepatic acini. They 
always occupied, however, the vascular spaces or the meshes of the 
network of hepatic cells, and these appeared quite normal except in 
the immediate vicinity of the cancer nodules, where the chains of 
hepatic cells were often flattened somewhat, as though by the pressure 
of the growth. At the margins of the growths, in many places, 
nearly all the meshes formed by the compressed hepatic cell- 
chains were occupied by the nucleated cell cylinders of the cancer, 
the atrophied secreting tissue of the liver here taking a position 
corresponding to that of the connective-tissue stroma of the more 
central portion of the cancer nodules. The cancer nodules then 
would appear to have grown by a continuous extension of their 
nucleated cylinders into the adjacent hepatic parenchyma, the 
secreting cells of which seem to perish by atrophy without con- 
tributing to the substance of the growth. (See Microscopical Sec- 
tion, Nos. 2389 to 2393.) 
No. 959, Medical Section. The greatly hypertrophied spleen. 
The spleen was nine and a half inches long, five and a half broad, by 
three thick in the middle. It weighed when fresh seventy ounces. 
Its margins presented several deep fissures (lobulated spleen). Be- 
neath the peritoneal coat were a number of small cancer nodules. 
Sections of these cancer nodules showed their structure to be quite 
similar to that of the cancer nodules of the liver, except that the 
meshes of the nucleated cylinders were more irregular and the 
cylinders themselves were in many parts somewhat thicker. The 
relations of the margins of these nodules to the hypertrophied splenic 
