The Minute Anatomy of Two Cases of Cancer. 119 
limits were *001 to • 002 inch. This would appear to depend 
simply upon the degree of emaciation which existed in the first 
case at the time of death. At all events the anatomy of that part 
of the adipose tissue which adjoined the morbid growth was 
essentially the same in both cases. Extension of the cancer 
cylinders into the connective-tissue septae between the fat-lobules, 
and the development of a more or less abundant nucleated matrix 
between the individual fat-cells of those lobules nearest the scirrhous 
tissue, were characteristic conditions in both cases. 
The first of the plates which illustrate this paper represents a 
portion of preparation, No. 3489, Microscopical Section, which is 
taken from this second case, magnified 400 diameters. It exhibits 
a side view of a part of the network of nucleated cylinders. The 
granular character of the protoplasm, the imbedded nuclei and the 
manner in which the nucleated cylinders interlace with the connec- 
tive-tissue stroma, are faithfully represented. The nuclei of the 
connective-tissue stroma are not so obvious, but few of them lying 
in the optical plane selected for representation. 
The second plate represents a portion of one of the liver nodules 
in the first case. It is copied from preparation No. 2393, Micro- 
scopical Section, magnified 400 diameters. The section divides 
several of the nucleated cylinders in a direction nearly perpen- 
dicular to their course, and they appear hence, as above described, 
not unlike so many multinucleated or mother-cells. 
Both photographs were made from carmine-stained prepara- 
tions, mounted in balsam, and in both, therefore, the nucleated 
cylinders appear shrunk away from the connective-tissue stroma in 
which they are imbedded. 
In conclusion, I must refer briefly to another interpretation of 
the nature and origin of such nucleated or cell cylinders as I have 
above described, which has been received with great favour for some 
few years. 
Thiersch in his work on epithelial cancer explains the cell 
cylinders in that form of carcinoma, especially of the skin, as out- 
growths from the lower layer of the epidermis and from the 
epithelium of the glandular apparatus.* Such an interpretation 
implies, of course, the possibility of demonstrating that the cell 
cylinders are continuous with the epithelial structures from which 
they are supposed to have budded forth. Such a continuity 
Thiersch believes himself to have observed in many of his sections. 
He admits, however, that it is often impossible to make it out, and 
explains this by supposing the connection to have originally existed 
but subsequently to have disappeared, pointing, in justification of 
the hypothesis, to the history of the normal development of the 
* 1 Der Epithelial-Krebs.’ You Dr. Carl Thiersch. Leipzig, 1865. Page 58. 
