PROGRESS OF MICROSCOPICAL SCIENCE. 
137 
which were partly at rest and partly in vibratory motion ; some of 
them exhibited a small process. By the sixth day these corpuscles 
had increased in size and number. Many of these larger ones exhibited 
the above-mentioned process ; and this then distinctly appeared as a 
bud. In a few it was so large that it was very little less than the 
parent cell. During the subsequent days the corpuscles continuously 
augmented in size ; so that a few soon attained the magnitude of 
shrunken red corpuscles, or even exceeded them. At the same time 
smaller ones of all sizes were present. Gemmation was frequently 
perceived, many corpuscles presenting not one bud only but several, 
which were in some instances pedunculated, and in others directly 
applied to the parent cells. Cases also occurred where the secondary 
buds appeared upon the surface of the primary ones. Most of these 
gemma) were of irregular form, but some were spherical. About the 
eighth or tenth day a vacuole formed within the larger corpuscles, 
which gradually increased in size till ultimately its walls appeared to 
consist only of a thin lamina, presenting a double contour under the 
microscope. At this period the corpuscles had attained their final de- 
velopment, and underwent no further changes even when the test 
could be preserved for a month, which of course was only of excep- 
tional occurrence. Dr. Lostorfer also examined the characters of the 
corpuscles with different fluids, as with solution of sugar, distilled 
water, and Pasteur’s fluid — namely, one-half per cent, of solution of 
common salt and one per cent, of solution of acetic acid. These fluids, 
notwithstanding their diversity, produced similar effects during the 
earlier period of the development of the corpuscles, causing them to 
shrivel, and preventing any further growth. Even at the sixth day 
some shrivelling occurred on the addition of these fluids and dilute 
solutions of sugar ; but when distilled water was added at this period 
the vacuolse enlarged rapidly. Gemmation took place in the form of 
long tubules, which closely resembled the germ tubes of fungi. The 
number of the corpuscles varied to a very great extent. In one in- 
stance he counted fifty of them in the field of the microscope at one 
time on the fourth day ; but he is unable to say whether any propor- 
tion exists between their number and the severity of the symptoms of 
syphilis present. Dr. Lostorfer states that long before the discovery 
of these corpuscles he had carefully examined the blood of healthy 
persons without finding anything similar to them ; and that during the 
last three months he has systematically subjected healthy blood speci- 
mens to the same treatment, as well as blood taken from those suffer- 
ing from gonorrhoea, diphtheritic ulcers, lupus, and from typhus 
patients, without in any instance observing their development. He 
therefore thinks he is justified in terming them syphilis corpuscles. 
He is of opinion that temperature is a matter of great importance 
affecting their development ; for when the temperature fell below a 
certain point, not yet exactly ascertained, the results were negative. 
He gives the appearances in thirteen cases, which show that the cor- 
puscles are not associated with any particular form or stage of syphilis, 
but manifest themselves both before and after the occurrence of the 
eruptions and in tertiary affections. He guards himself from saying 
