( 33 ) 

 NEW BOOKS, WITH SHORT NOTICES. 



Wo have been compelled, owing to pressure on onr space, to 

 "crush out" for the present month notice of the following works : — 



The Microscope and Microscopical Technology, by Dr. Frey. 

 Translated by Dr. E. Cutler. 



Manual of Human and Comparative Histology. Edited by S. 

 Strieker. Translated by H. Power, M.B. Vol. III. ^ 



Experimental Eesearches on the Causes and Nature of Hay-Fever, 

 by C. H. Blackley, M.E.C.S. 



A Manual of Pathological Histology, by Dr. E. Eindfleish. 

 Vols. I. and II. Translated by E. B. Baxter, M.D. 



The Philosophy of Evolution : An Actonian Prize Essay, by 

 B. T. Lowne, M.E.C.S., Lecturer on Physiology at the Middlesex 

 Hospital ; and 



Eevue des Sciences Modicales en France et a I'Etranger, dirige 

 par Georges Hayem. Tome I., No. 1. 



PEOGEESS OF MICROSCOPICAL SCIENCE. 



The Development of Cancer. — In a late number of Virchow's 

 ' Archiv,' Dr. Carmalt records the results of the examination of three 

 carcinomatous tumours, removed from the skin of the nose, the cheek, 

 and the eyelid. Thiersch, in his work on cancer, has pointed out that 

 the epithelial cells of the sebaceous and sweat glands, and especially 

 the cells of the rete Malpighii, are often the j)oint of departure for 

 cancer of the skin, and he casually includes the epithelium and the 

 hair-follicles in the same category. In the hair-follicles Dr. Carmalt 

 found not only an increase of the outer layer of epithelium, but also 

 offshoots from the follicles, diverticula lined with epithelium, pene- 

 trating the connective tissue to various depths and in various direc- 

 tions. A section made either obliqxiely or parallel to the axis of the 

 follicle, and passing through the diverticula, gave exactly the appear- 

 ance of the ordinary cancer-alveoli, filled with epithelial cells. In 

 certain preparations, it was possible to see the alveolar groupings of 

 the cells pass into long processes lined with epithelium, which, again, 

 opened into the hair-follicle ; so that the appearance was that of a 

 group of acinous glands with their excretory duct. Other sections 

 presented a still more complete picture, viz. the enlarged follicles and 

 their offshoots, the alveolar groixps of epithelial cells, evidently in 

 connection with the follicular offshoots, and lastly, isolated ei^ithelial 

 alveoli, situated more deeply in the tissues, and showing^ he ordinary 

 characters of cancer-alveoli. Carmalt thinks it is hardly to be doubted 

 that these isolated cancer-alveoli were also originally in continuity 

 with the hair-foliicles and their diverticula. 



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