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animals. On the other hand, animals kept from-all possible contagion 
were affected as strongly as others. 
The premonitory symptoms of the disease were, generally, a loss of 
appetite, apathetic dullness, prostration, drooping head and ears, a 
staring coat of hair, watery or glassy eyes, and a thin discharge of 
mucus from the nose. As the disease advanced these symptoms were 
intensified. The joints became stiff, and a peculiar cough, sometimes 
described as sharp and hacking, and sometimes as deep in the chest, 
seemed to rack the whole animal system. Muscular exertions would 
sometimes excite this cough to distressing paroxysms. Fever set in, and 
the blood circulated with abnormal activity in the head, neck, and body, 
while it almost deserted the ears and legs, leaving them unnaturally 
cold. The mouth was hot, and the nasal membranes, in some cases, 
were congested. The nasal discharge became more copious and offensive, 
varying in color from white to green, and often stained with blood. The 
animal obtained great relief from the free discharge of this purulent 
matter. The lungs and throat sympathized with the other organs, and 
showed signs of acute inflammation. The breath was labored and pain- 
ful. In more severe cases the brain was affected, a symptom which 
generally indicated a fatal termination. ; 
The average continuance of the disease in individual cases varied con- 
siderably, the extreme range being between five days and forty-five 
days, the minimum being in Franklin County, North Carolina. The 
averages were somewhat greater east of the Alleghany Mountains. In 
Maine, the county averages ranged from 10 to 25 days, the State aver- 
age being 16. New Hampshire reports a longer continuance of the dis- 
ease, the counties ranging from 21 to 42 days, and the State averaging 
30. In the other New England States the period was shorter; Vermont 
averaging 20; Massachusetts, 20; Connecticut, 23. In the Middle 
States the county averages ranged from 9 to 42 days, the shortest period 
being reported in Cattaraugus, New York. The State of New York 
averaged 20 days; New Jersey, 25; Pennsylvania, 23. The Atlantic 
Coast States varied between five days (in Franklin County, North Caro- 
lina) and 42 days. The State averages were as follows: Maryland, 26 
days; Virginia, 21; North Carolina, 21; South Carolina, 26; Georgia, 
21. The Gulf States varied between 8 days and 42 days, the shorter 
period being reported in Lauderdale and Limestone Counties, Alabama. 
Florida averaged 19 days; Alabama, 20; Mississippi, 21; Louisiana, 
22; Texas, 21. Theinland Southern States ranged from 10 to 45 days, 
the minimum being in Pocahontas County, West Virginia, and the 
maximum in Davies County, Kentucky. Arkansas averaged 19 days; 
Tennessee, 21; West Virginia, 18; Kentucky, 20. North of the Ohio 
River the county averages ranged from 10 to 42 days. Ohio averaged 
20 days; Michigan, 23 ; Indiana, 23; Illinois, 23; Wisconsin, 22. West 
of the Mississippi the disease prevailed from 10 to 35 days; Minnesota 
averaged 24 days; Iowa, 23; Missouri, 19; Kansas, 21; Nebraska, 22. 
The reports from the Territories were too few for a reliable average. 
In California one county, San Joaquin, averaged 12 days. 
As a general thing the severity of the visitation in different localities 
may be estimated from the length of its continuance. This rule, how- 
-eyer, is not without exceptions, and should be applied with due caution. 
‘The period was often unnecessarily lengthened by abuse, neglect, or 
hard work before final recovery. Thisill treatment not only protracted 
the preliminary attack, but also brought on relapses, which terminated 
‘in dropsy, pneumonia, or other forms of acute disease, from which few 
