84 THE MICROSCOPE. 



but which goes very much in detail and not only takes up drugs by 

 classes (roots, barks, leaves, etc.,) but shows with every drug separ- 

 ately how to treat it previous to section-cutting, and how to apply 

 reagents to differentiate in the best way the structure, etc. Prof. 

 Harrington has completed a more extended work than his pamphlet, 

 which covers much of the ground here proposed, but it still exists 

 only as manuscript, and will very likely remain in his desk for a 

 long time. Plenty of stray notices will be found in Berg, Schacht, 

 Wigand, Sachs, Vogl, Nageli, Dippel, Hager, Fluckiger, Planchon, 

 and others, not to mention treatises on the use of the microscope in 

 medicine nor the various microscopical journals and articles, but 

 in order to get at them we have to take so many things into the 

 bargain which we feel much interested in. 



I should think that Mr. E. B. Stuart, Chicago, or Mrs. Louisa 

 Reed Stawell, Ann Arbor, Mich., would be eminently fitted for 

 writing such a manual." — H. M. Wilder, in American Journal 

 Pharmacy. 



[Will Mr. Wilder please read the article " Microscopy in the 

 University of Michigan." — Ed.] 



Microscopical Appearances of the Nervous Tissues of the 

 Insane. — In the brains of patients who suffered from chronic insan- 

 ity the microscope revealed atrophy of circumscribed areas of gray 

 matter, and wherever adhesions had existed between the cortex and 

 the pia, profound pathological changes and even total destruction 

 of the gray matter. Pigmentation and degeneration of nerve cells 

 and their processes, patches of induration involving destruction of 

 cells and fibres, minute points of softening, lymphoid infiltration, 

 and amylaceous bodies have been noted. The arteries were often 

 atheromatous, enlarged, contracted at one point and bulging in 

 others, their coats thickened and nuclei increased, with fatty and 

 lymphoid infiltration of the adventitia, deposits of pigment at their 

 branchings and in the perivascular spaces. Aneurismal dilata- 

 tions of the capillaries and thromboses of the smallest vessels have 

 been demonstrated. 



In epileptic insanity the cortical cells have usually been found 

 well preserved. The arteries have generally been found larger than 

 normal, somewhat tortuous, and their coats hypeitrophied, but with- 



