40 
In  some  cases  various  treatments  were 
tried  before.  Mercurial  injections,  “914”,  “606”, 
so-called  detergents,  general  tonics,  besides 
different  forms  of  diet.  Notwithstanding,  the 
disease  persisted  or  went  on  impressive  and 
dreadful.  In  our  first  preliminary  note  we  said 
that  the  patient  had  been  treated  with  large 
doses  of  potassium  iodide.  To-day,  on  the 
strength  of  more  observations,  we  may  de¬ 
clare  that  not  only  potassium  but  also  so¬ 
dium  iodide  (sometimes  preferable  to  the 
former)  exercises  on  the  Oidium  brasiliense 
a  similar  action,  as  the  former  shows  on 
the  sporotricha. 
In  vitro ,  the  iodide  solutions  do  not  pre¬ 
vent  the  development  of  the  O.  brasiliense , 
even  acting  for  a  long  time  in  concentrated 
solutions  (high  dose)  ;  apparently  the  colo¬ 
nies  do  not  even  appear  later. 
The  iodides  have  been  given  by  mouth  and 
intravenously.  After  testing  the  sensibilitiv 
and  the  kidney  conditions  of  the  patient,  we 
determined  the  doses  which,  wityout  reaching 
the  yighest,  used  in  Norty-America  (30 
and  50  grams),  oscillated  between  8  e  12 
grs.  daily.  For  intravenous  injection  we  em¬ 
ployed  isotonic  solutions,  preferring  those  of 
sodium.  The  technique  of  diese  injections  is 
weil  known.  We  may  use  common  syringes 
or  special  dispositions  facilitating  the  opera¬ 
tions  (see  figure),  as  used  by  prof.  SAMUEL 
LIBANIO  and  his  assistants. 
The  vehicle  of  the  solutions  for  these 
injections  is  bi-distilled  and  recently  sterili¬ 
zed  water.  The  iodide  is  chemically  pure 
(BERTRAND).  We  always  inject  very  slo¬ 
wly. 
After  some  days  of  treatment,  the  aspect 
of  the  patient  changes.  The  emaciated,  par¬ 
ched  and  pale  face  becomes  smooth,  full 
and  coloured.  Anemia  disappears.  Increase 
in  number  of  red  bloodcorpuscles  and  per¬ 
centage  of  hemoglobin  succeeds  to  diminu¬ 
tion  of  the  former  and  to  the  low  percenta¬ 
ge  of  the  latter.  When  anorexia  existed,  it 
was' succeeded  by  a  canine  appetite  and  ge¬ 
neral  depression  is  succeeded  by  gradual  re¬ 
cuperation  of  forces.  Hemoptysis  is  arrested. 
The  hemoptoic  sputum  tends  to  disappear 
while,  on  continuing  the  treatment,  the  proper 
expectoration  ceases.  These  modifications  are 
followed  by  others  in  the  pulmonary  paren- 
ch  ma,  as  shown  by  physical  examination.  The 
lesions  regress.  One  of  our  cases  relapsed, 
due  to  interruption  of  treatment  with  iodine. 
(These  recidives  are  frequent  in  sporotricho 
sis).  Another  side  of  the  treatment  to  be  con¬ 
sidered,  is  the  individual  intolerance,  but  this 
is  a  personal  factor  which  cannot  influence 
the  general  rules  of  treatment. 
For  the  intravenous  injection  we  used 
an  apparatus  shown  in  one  of  the  plates. 
In  some  cases  of  intravenous  injection 
we  noticed  that  the  solutions  of  sodium,  and 
especially,  those  of  potassium  iodide,  were 
very  painful  and  irritating,  when,  as  someti¬ 
mes  happensyin  these  operations,  some  drop 
of  the  solution  casually  went  in  the  sheath  of 
the  vein  or  even  in  the  neighbouring  tissue. 
Using  chemically  pure  iodide,  we  may  avoid 
this  inconvenience,  partly  but  not  wholly,  and 
therefore  we  use  our  apparatus.  In  iso¬ 
tonic  solutions  the  concentration  does  not 
require  large  quantities  of  liquid  for  the  injec¬ 
tion  of  large  doses  of  iodide.  This  apparatus 
consists  of  2  tubes  A,  and  B.,  both  of  a  ca¬ 
pacity  of  50  cc.  The  end  of  the  upper  extre¬ 
mities  of  the  tubes  is  formed  by  a  dilation, 
full  of  cottonwool  for  the  filtration  of  any  air 
we  may  wish  to  let  penetrate  under  pres¬ 
sure.  The  lower  part  of  the  two  tubes  com¬ 
municates  with  a  single  tube  of  discharge  D, 
provided  with  rubber  tube  and  needle.  At 
the  level  of  connexion  there  is  a  stopcock 
C  which,  by  its  inner  orifices,  lets  D  commu¬ 
nicate  either  with  A  or  with  B  or  completely 
stops  the  passage  of  the  liquid.  Tube  A  con¬ 
tains  the  physiological  solution,  tube  B  isoto¬ 
nic  solu'.'on  of  8,5  0/00.  The  needle  is  washed 
by  a  discharge  of  physiological  salt  solution. 
For  the  construction  of  this  apparatus  we 
are  indebted  to  the  obsequiousness  of  Mr. 
MANOEL  GOMES.  The  needle  is  introduced 
into  the  vein,  after  putting  D  in  communica¬ 
tion  with  A.  We  verify  carefullv,  if  the  liquid 
really  penetrates  into  the  vessel.  Now  we 
effect  the  communication  between  D  and  B, 
repeating  after  the  injection  the  washing 
