THe Microscope. 147 
ago, experiments were made with reference to the poison of 
rabies. It was then satisfactorily demonstrated that the poison 
was not volatile, that its vehicle is the saliva, and papulum the 
salivary glands of rabid animals, and that it does not exist in 
the nervous pulp, which in a putrid condition is now being em- 
ployed by Pasteur and his followers for prophylactic inocula- 
tions. These experiments and observations were repeated and 
the facts verified by such authorities as Trolliett, Berschet and 
Majendie. Of fifty-nine dogs inoculated with saliva fourteen 
became rabid. It was also established by statistics that but 
one person in eighteen or twenty bitten by rabid animals be- 
came infected with the disease, and it has long been known 
that hydrophobia, or water dread, is not constant in rabies, and 
that it may be concomitant in the morbid conditions including 
blood poison diseases. Without extending references, the 
above is sufficient to raise a doubt as to whether Pasteur has 
found or is using the poison of rabies in the putrid brain infu- 
sion with which he is operating. 
But that Pasteur is operating with an infectious poison 
there can be no doubt, and a brief reference to one of the 
forms of septiczemia from inoculation with putrid meat infusion 
may throw some light on the subject. From an extended series 
of experiments Dr. Sanderson names the following symptoms 
as characterizing septiczemia with inoculation with putrid meat 
infusion: ‘“Dullness of the eyes, with increased conjunctival 
secretion, finally gluing the lids together.” Pasteur, it would 
appear, regards this as almost pathognomonic of rabies. “ At 
first the animal moved but little, was languid, had loss of appe- 
tite, weakness and slowness of respiration and circulation.” 
These symptoms were succeeded by “restlessness, insane acts, 
muscular twitchings, spasms and death.” These are the symp- 
toms then to be expected in this form of septicaemia, and they 
are, substantially, what Pasteur claims to produce in modified 
form by his inoculations. There is a strong probability, there- 
fore, that investigations pushed however far with Pasteur’s 
inoculation fluid will not discover the real poison of rabies nor 
result in prophylaxis, unless from similarity rather than iden- 
tity of poison, which claim, so far as I know, has not been set 
up. There is an equally strong probability, too, that the poison 
