176 C. M. BROOM ALL : GLYCOGENIC FUNCTION. 



at those points where energy is needed, we may assume that 

 the ferment is secreted by the pancreas as a zymogen and that 

 the active oxidase is only released where the conditions are 

 suitable — in other words, where such energy is needed. As 

 remarked above, any sugar in the circulation that is not com- 

 pletely oxidized, or that has passed the liver without conver- 

 sion, is transformed into glycogen by the living cells of the 

 muscular tissue and stored away in that form until needed. 



In conclusion, if the above theory is sound, there ought to 

 exist, aside from the mixed types, three distinct kinds of dia- 

 betes mellitus : (i) Physiological, due to overloading the 

 system with carbohydrate food ; (2) That due to inability of 

 the cells to convert and store away the sugar as glycogen, and 

 (3) That due to deficiency of the oxidase in the internal 

 secretion of the pancreas. The first two types are well known 

 and the tact that extirpation of the pancreas is followed by 

 the appearance of sugar in the circulation certainly indicates 

 the possibility of the existence of the third type. 



