Chloroform, Prussia Acid, &c., on the Blood. 79 



Experiment 4, — Frog immersed in a four-grain solution of the 

 hydrate for some hours, when it was found hypnotic. Blood, nuclei 

 of corpuscles appeared greenish, red particles also seen. 



Experime7it 5.— Frog killed by hydrate of chloral, after some 

 hours of sleep. Blood from heart decidedly tinged redder than 

 usual ; some corpuscles presented reddish dots on their surface ; red- 

 coloured masses were noticed all through the blood, as seen before. 



Experiment 6. — On self. Three grains of hydrate of chloral 

 were taken about two hours after a meal ; the blood was examined 

 every quarter of an hour ; at the end of an hour it exhibited 

 decided reaction ; blue as well as red particles were seen. When 

 the blood had dried on the glass slide and under the covering glass 

 (which was about two hours after), some spaces, where coagulation 

 had taken place, were filled with fluid presenting either a bluish or 

 reddish tint. The urine also exhibited some dark-coloured and 

 reddish particles. 



Experiments 7 and 8. — Two rats were killed, one by chloroform, 

 the other by hydrate of chloral, injected subcutaneously. This last 

 took a grain and a half before deep sleep was induced. Blood 

 exhibited ruby-red particles ; a few bluish ; also starchy bodies in 

 abundance. The urine also showed the same. 



The chloroformed rat. — Urine witK abundance of starchy 

 bodies, and some blue-coloured particles ; blood from lungs — plasma 

 reddish ; few starchy bodies ; some blue particles ; scarcely any 

 reddish. 



Experiment 9. — Eat injected with hydrate of chloral. Deep 

 hypnotism ; blood gave the same results ; starchy bodies and red- 

 coloured masses. Ammonia inhaled appeared to increase the pro- 

 duction of the red matter. A solution of ammonia injected under 

 the skin appeared to give rise to bright red smears, or fluidity, 

 between the corpuscles. The blood, under the action of ammonia, 

 in both forms of exhibition, seemed to have assumed a redder tint 

 than usual. 



Experiment 10. — A newly-born rat was placed in a solution of 

 hydrate of chloral. After some hours the blood exhibited redness in 

 the liquor sanguinis ; also some fine red particles and red patches. 



Experiment 11. — Hydrate of cliloral was evaporated from a 

 slide on to fresh blood held over it ; bright red-coloured particles 

 were formed in it. 



Experiment 12. — Blood exposed to the vapour of chloroform 

 gave some evidence of red-coloured matter. It appeared to me, at 

 this point of my experiments, that the chemical action of hydrate of 

 chloral on the blood was mainly due to formyl, or formic acid, 

 produced by its decomposition. When more ammonia was intro- 

 duced into the experiment, a larger production of the red material 

 resulted. 



