NOTES AND MEMORANDA. 113 



quinine npon infusoria, I determiued at once to make an experiment 

 with that substance, thinking that these vibriouic bodies, even if they 

 did not cause the whole illness, still could render it much more un- 

 pleasant through their movements and the decompositions caused by 

 them. For that reason I made a neutral solution of sulphate of 

 quinine, which did not contain much of the salt (1-800), but still was 

 eflfective enough, and caused moderate irritation of the mucous mem- 

 brane of the nose. I then lay flat upon my back, keeping my head 

 very low, and poured with a pipette about four cubic centimetres into 

 both nostrils. Then I turned my head about in order to let the liquid 

 flow in all directions. 



" ' The desired effect was obtained immediately, and remained for 

 some hours ; I could expose myself to the sun without fits of sneezing 

 and the other disagreeable symptoms coming on. It was sufiicient to 

 repeat the treatment three times a day, even under the most unfavour- 

 able circumstances, in order to keep myself quite free. There were 

 then no such vibrios in the secretion. If I only go out in the evening, 

 it suffices to inject the quinine once a day, just before going. After 

 continuing this treatment for some days the symj)toms disappear com- 

 pletely, but if I leave off they return till towards the end of June. 



" ' My first experiments with quinine date from the summer of 

 1867 ; this year (1868) I began at once as soon as the first traces 

 of the illness appeared, and I have thus been able to stop its develoj)- 

 ment completely.' " 



NOTES AND MEMOEANDA. 



Precious Stones in the Construction of the Microscope. — 



M. H. Brachet addressed a note to the French Academy (June 22nd) 

 on the employment of artificial precious stones in the comj^ound 

 microscope. This paper, which has not yet been published, was sent 

 to the ' Commission du Prix Tremont.' 



A Remedy for Phylloxera. — At a meeting of the French Aca- 

 demy of Sciences, June 29th, a paper, forming a Eeport, was read on 

 the administrative measures to be taken for the preservation of terri- 

 tories threatened by Phylloxera, by the Commissioners. It is sug- 

 gested to the Academy that a special law should be made compelling 

 proprietors to declare the first appearance of the scourge, that experts 

 should then be appointed to examine into the state of the infested vines, 

 and that these should be destroyed when thought necessary by minis- 

 terial decision, the proprietor receiving adequate compensation. It is 

 further suggested to destroy the vines surrounding the districts ac- 

 tually invaded, to disinfect the soil by chemical methods, and to burn 

 the cuttings, leaves, and roots of the diseased plants as well as the 

 plants themselves in the same district where the uprooting has taken 

 place, and finally to prohibit with the utmost rigour the exportation 



