Osteoid Cancer of the Left Femur. 123 



granular, but little altered in shape. The tumour is not very- 

 vascular, the blood-vessels being few in number and rather large 

 in size ; their walls are very thin, and are composed of fine fibrous 

 tissue surrounded by round and fusiform cells corresponding to 

 those found in other parts of the growth. 



2nd. Not even a trace of glandular arrangement remains to 

 indicate the original nature of the mass ; it is extremely dense, 

 much more so than the primary growth, and consists of numerous 

 calcareous spicule radiating from the centre to the circumference, 

 forming long, narrow meshes, wherein are to be seen, closely 

 packed, numberless round cells, agreeing in character with — but 

 rather larger than — those of the primary deposit. In no situation 

 do they show signs of fatty degeneration. The glands are fused 

 together and surrounded by a capsule composed of loose connective 

 tissue which is firmly adherent to the mass. The blood-vessels are 

 more numerous than in the first specimen, and their walls are 

 calcified. 



3rd. In structure these glands are identical with No. 2, 



4th. The structure of these masses, small and large, corresponds 

 to that above described. The calcareous matter is deposited prin- 

 cipally in the fibres surrounding the vessels, which are here (as in 

 Nos. 2 and 3) more numerous than in the growth from the femur. 

 The stroma is more loosely arranged, and in some parts it is soft, and 

 dimly granular, resembling the matrix of hyaline cartilage ; multi- 

 tudes of cells are seen filling np the alveoli of the growth and 

 distending the adjoining air-cells of the lungs ; the growth thus 

 seen invading the pulmonary alveoli consists of round nucleated 

 cells without stroma. All that can be discerned in these morbid 

 masses, of the normal structure of the part, is a beautifully preserved 

 plate of hyaline cartilage, here and there the only landmark of an 

 obliterated bronchus. The lung tissue and the morbid deposits 

 therein are much pigmented. 



The appearance of these growths (with the single exception of 

 the absence of true lacunx) agrees with those usually described 

 under the name of peripheral osteo-sarcoma, or osteoid cancer of 

 Miiller, and as such I should regard them. 



K 2 



