PROGRESS OF MICROSCOPICAL SCIENCE. 201 



bodies, there were largo masses of lyuiplioid substance of similar 

 structure. The spleen itself was remarkable for its great richness in 

 granular blood-colouring matter and cells containing blood-corpuscles, 

 as well as for a great amount of small and largo fat-drops. The blood 

 of the splenic vein was fluid, and of a clear red colour, and contained 

 about one white corpuscle to ten or fifteen red ones. There was a 

 slighter increase of the white corpuscles in the blood of the coronary- 

 veins of the heart, where the proportion was about 1 to 30 or 4(). 

 The liver was of a pale coffee colour, of normal size, and rather 

 anfemic. The kidneys were of usual size ; the capsule was easily 

 removed, and on the surface beneath it were some cicatricial contrac- 

 tions. The substance of the kidneys was of a clear brown colour, 

 and fragile. On microscOi)ic examination, there was found to be 

 marked fatty degeneration of the epithelium of the urinary tubules. 

 The bladder was full of clear yellow urine, having a neutral reaction, 

 and throwing down a flocculent deposit of albumen on being heated. 

 On microscopic examination, instead of the cylinders that were ex- 

 pected, there were found numerous round nucleated cells, having the 

 appearance of colourless blood-corpuscles, and a few spermatozoa. 

 The mucous membrane of the bladder and urethra was normal. The 

 stomach and intestine did not present any remarkable change. There 

 was no enlargement of the lymphatic glands anywhere. 



This case of simjjle splenic leucocythaemia, in which, besides the 

 large lymphadenoma of the sj^leen, there was only a moderate increase 

 of the colourless blood-corpuscles, can, without doubt, be ajiplied in 

 the direction indicated above. The disease was seized in its early 

 stage, before it had gone on to metastasis, and to leucocythasmic 

 disease of other organs. The remarkable amount of colourless blood- 

 corpuscles in the urine, while the urinary passages were in a normal 

 state, may perhaps be attributed to escape of the too abundantly 

 formed cells into the diseased renal tissue ; yet the simultaneous 

 occurrence of spermatozoids in the urine indicates that there might 

 possibly have been another source for these cells. 



A further case of lieno-lymphatic leucocythsemia in the dog has 

 been observed by Siedamgrotzky, of Dresden ; * so that, in all, three 

 cases of leucocythaimia in the dog have been fully described. The 

 essential features of the case referred to were the following : — 



A four-year old spaniel, which had suffered for some time from 

 loss of appetite and from diarrhoea, died four days after admission 

 into the veterinary hospital. A large firm tumour had been detected 

 in the abdomen by palpation. At the necrojisy, the spleen was found 

 to weigh about 2f lbs. ; it was much enlarged, and was covered with 

 flat projections on the surface. All the lymphatic glands, especially 

 the mesenteric, were remarkably enlarged ; as were also the tonsils. 

 The proportion of white to red corpuscles in the blood was 1 to 15. 

 There were sanguineous effusions in the spleen, on the pericardium, 

 in the mucous membrane of the tonsils, and on the gums. 



Siedamgrotzky also describes a slight degree of lieno-lymphatic 

 leucocythfemia as having been foimd in a cat which had died of internal 

 * Boricht iibcr das Veteriuarwesen im Kouisreich Sacbsen fiir das Jalir 1871. 



