19= • THE MICROSCOPE. 



I might increase this list, but do not feel justified in using the 

 names without permission. 



As to Dr. Heitzmann's criticism of my drawing, I will only say 

 that I had supposed a drawing for scientific purposes to be good, 

 not as it left out objectionable details and improved upon those 

 represented, but just in proportion to the accuracy with which it 

 reproduced the appearance seen. It has always been my aim to 

 represent objects as nearly like what I saw as I could. Any other 

 ■course has seemed to me to be not only bad drawing, but absolute 

 dishonesty. 



While engaged in these studies, I met with certain bodies which 

 I have not seen described elsewhere just as I have seen them, 

 ■although Dr. Osier and others have spoken of having seen some- 

 thing like them in the blood of the lower animals. 



The bodies are minute granules. They can be seen in blood, 

 ■with a good high-power glass, without the addition of any re-agent, 

 but are best seen after staining. If, while studying blood with the 

 microscope inclined, a drop of carmine staining fluid be placed at 

 the upper edge of the covering-glass, there will be seen bright red 

 points sliding across the field of the microscope long before any 

 other evidence of staining appears. As the staining fluid comes 

 down further, the points increase in number, until finally, when the 

 field of the microscope has been entirely traversed, they are count- 

 less. Under a magnifying power of twelve hundred diameters, 

 they appear as minute, round bodies. Their small size renders a 

 measurement of them difficult; but I have estimated their diameter 

 at from 1-20,000 to 1-40,000 of an inch. They stain deeply with 

 carmine, and are highly refractile, the stained ones appearing as 

 bright red points surrounded by a black rim. The width of this 

 rim varies as the focus is changed; when they are slightly beyond 

 the focus, the red point disappears, and they show as black dots. 



I have seen these bodies in the blood of every person which I 

 have examined, with one exception. I studied the blood of Mr. 

 Griscom during a long fast which he underwent in Chicago. VoT 

 part of this fast these bodies were absent. During their absence I 

 observed many granular white corpuscles of exceptionally large size. 

 They seemed to be composed of sperules of about the same size as 

 the granules before described. The corj)uscles often had an active 

 amoeboid movement. At this time the granules flowed out into the 



