Diseases of the Circulatory System 187 



It had an elevation of nearly 3 degrees of temperature. An 

 examination of the blood showed a marked diminution in 

 the nmnber of red corpuscles and an increase in the number 

 of white ones. In the disease produced artificially by feed- 

 ing cultures of the specific organism there was in most cases 

 a marked drowsiness and general debility manifested from 



1 to 4 days before death occurred. The period during which 

 the prostration was complete varied from a few hours to 

 two days. The mucous membranes and skin about the 

 head became pale. There was an elevation of from 1 to 4 

 degrees of temperature. The fever was of a continuous type. 



"Although the course of the disease in the different fowls 

 was usually constant, there were many variations. In a 

 few individuals the time required for fatal results was from 



2 to 3 weeks, but ordinarily death occurred in about 8 days 

 after feeding the virus, the rise in temperature being detected 

 about the third day and external symptoms about the fifth 

 or sixth, occasionally not until a few hours before death. 

 The symptoms observed in the cases produced by feeding 

 correspond with those described by the owners of affected 

 flocks." 



Moore found the only constant lesions to be in the blood 

 and liver. The change in the blood as noted above was a 

 decrease in the number of red and an increase in the num- 

 ber of white cells. The change in the liver is described by 

 Moore as follows: 



"The liver was somewhat enlarged and dark colored, 

 excepting in a few cases in which the disease was produced 

 by intravenous injections. A close inspection showed the 

 surface to be sprinkled with minute grayish areas. The 

 miscroscopic examination showed the blood spaces to be 

 distended. The hepatic cells were frequently changed, so 

 that they stained very feebly, and not infrequently the cells 

 were observed in which the liver cells appeared to be dead 



