Prog) CSS of Foreign Science. 327 



silky nysials, entirely soluble in alcohol, scarcely soluble in 

 cold water, but more in boiling water, particularly if this was 

 slightly acidulated. They consist of pure sulphate of quinina. 

 Messrs. Pelletier and Caventou, while they approve of the above 

 process, consider the product as overrated, probably from M. 

 Henry not having sufficiently dried the sulphate obtained. The 

 pure sulphate of cinchonina o-ioht to be brilliant, crystallized in 

 parallelipeds, very hard, and of a glassy white ; the sulphate of 

 quinina is on the contrary of a dull white, silky and flexible ; 

 both should be soluble in alcohol and should burn without leav- 

 ing any residuum*. 



In the Journal de Pharmacie for last September, M. Baup, of 

 Vevai, describes the crystallized sulphate and supersulphate of 

 quinina, as consisting, the first of — 



Quinina . . 1 atom 45 



Sulphuric acid . .1 — 5 



Water . . . 4 _ 4.5 



The supersulphate consists of- 



Quinina 



Acid 



Water 



54.5 



73 



The crystalline form of cinchonina is a rhomboidal prism, of 

 108° and 72°, terminated by a bevelment. 



M.M. Pinel, Thenard, and Halle, in a report recently made 

 to the Academy of Sciences, on a Memoir of M. Choulant, en- 

 titled, " Observations on the employment of the Sulphates of 

 Quinina and Cinchonia in Intermittent Fevers," give the fol- 

 lowing conclusions : The number of cases reported by M. 

 Choulant is 14; in 10 of them the cessation of the fever was 

 due to the sulphate of quinina, which occurred immediately 

 after either the first or the second dose ; and, in the latter 

 case, the paroxysm that followed the first was considerably 

 milder; the effectual doses varied from 6 to 12 grains. The 

 reporters also state, that M. Double has administered the sul- 

 phate of quinina in tertian and quartan agues, with immediate 

 and complete success, and almost always after the first doses. 

 The small bulk of the medicine renders its administration easy 

 in many cases in which the bark in substance would be inad- 

 missible. The red or yellow bark seems to yield the most 

 febrifuge quinina. 



VI, Analysis and Apparatus. — In the last Number of 



* Jmiin (li Phurm. .Iiilv, 1H'21. p. ;U),'). 



