On the Fluctuations in the Number of white Blood Corpuscles etc. 67 



The result of the differentiation is, therefore, that the polynu- 

 clear cells increase by 4 °/o and that the reduction in the number 

 of the mononucleated only affects the large cells. And this result 

 is not arrived at from one single preparation dominating the whole, 

 but is found generally in all the preparations. 



If we now draw up a scheme similar to that shown above for 

 the changes in position, in order to exhibit the influence of the 

 meal-time, it will appear as follows. 



Pulse frequency increases 



Calibre of artery increases 



Diastolic blood-pressure decreases 



(Pulse-pressure increases) 



Temp, in mouth rises 



Temp, on forehead rises 



Number of leucocytes increases 



Comparing this with the previously given scheme it is readily 

 seen, that the frequency of the pulse and the calibre of the arteries 

 cannot have any determinative influence on the fluctuations in the 

 number of leucocytes. This has already been pointed out by Has- 

 selbalch and Heyerdahl so far as the frequency of the pulse is 

 concerned. According to the same authors, the heightened temper- 

 ature of the skin cannot come into consideration either, as blood 

 from the skin made strongly hyperæmic by a chemical light-bath 

 did not show an increased number of leucocytes. In the bath 

 experiments of H. & H. the blood pressure increased with the 

 number of leucocytes, whereas the reverse was the case in both my 

 series of experiments. Of the hitherto examined functions there 

 remains therefore the pulse-pressure as possible cause of the varia- 

 tions. М3' data on the pulse-pressure are as mentioned not exact, 

 but the changes are nevertheless so great that we may consider 

 them as real, for example, in the investigations before and after 

 meals as also in the majority of the observations on the changes 

 produced by change in position. The presumption finds confirma- 

 tion in the last cases from other and more exact investigations Ч 



It seems to me reasonable to conclude from the data that the 

 rapidly occurring and quickly disappearing л'ariations in the number 

 of leucocytes, as the result of changes in position, meals, bodily 

 movements of short duration or varying outer temperature, arise 



^ Heyerdahl: Om Sammenhæng mellem Antal af hvide Blodlegemer og Variationer 

 i Pulstryk. 



