680 REPORT OF THE COMMISSIONER OF AGRICULTURE, 



had spread over tlie entire body by way of tlie blood and lymph 

 channels. 



The author calls attention to the great resemblance between the 

 inoculation disease produced by him and by Loffler, and considers 

 the cause the same in both cases, 



A pig which had been made insusceptible to rouget by vaccination 

 was inoculated with a pure culture of this oval bacterium. It died 

 in two or three days, with extensive local swellings where the inocu- 

 lation had been made. Bacteria in all the organs; especially numer- 

 ous in the spleen. This case illustrated the fact that an animal made 

 insusceptible to one disease is not necessarily protected against the 

 virus of another, 



Schlitz was unable to produce the disease by feeding, as the fol- 

 lowing shows : After starving a pig for twenty-four hours it was fed 

 with bouillon in which 5 per cent, sodium carbonate was dissolved, 

 and half an hour later with one liter of blood and pieces of flesh from 

 a pig which had succumbed to inoculation. The animal seemed 

 slightly ill for a few days, but recovered. 



In continuing these investigations an epidemic came to his notice 

 in which the early symptoms were diarrhoea, sometimes bloody. At 

 the same time the hind legs became stiff, so that the animal lay most 

 of the time. On the sixth and seventh day the back became weak, 

 so that in walking the animals swayed to and fro. They then were 

 scarcely able to reach their food without tumbling over. In a few 

 the ears became red. In all the breathing became labored and hur- 

 ried. In some twitching and convulsions appeared before death, 

 which occurred on the eighth to the tenth day. Without giving the 

 comxjlete autopsy notes it will suffice to say that there was nothing 

 abnormal in the intestinal tract. The stomach was considerably 

 bile-stained. The lesions were limited to the thoracic cavity. In the 

 pericardial cavity about 36 grams of an opaque reddish fluid. Peri- 

 cardium and epicardium glued together by small quantities of a 

 warty, stringy, elastic substance: 



Both lobes of the left lung, with the exception of the upper border and the four 

 lobes of the right lung, tough and" airless (hepatized). In both pleural sacs about 64 

 grams of an opaque reddish-yello\^ fluid, mixed with flakes of fibrin. The pleura 

 covering the hepatized portions was rough, dull, clouded. These were in general of 

 a dark grayish red, with interspersed, circumscribed patches of various size and 

 form and grayish-yellow or reddish-yellow in color. * * * On the cut surface of 

 the hepatized portion grayish-red and reddish-yellow areas could be detected, which 

 were sharply marked oft" from one another. They corresponded to the circum- 

 scribed patches on the pleura,, were very friable, partly with a pale luster, partly 

 gi-anulated. They occupied larger volumes of lung tissue, or were sprinkled as 

 scattered foci in tlie grayisli-red portions. Their extent was limited by the course 

 of the larger bronclii and blood vessels. The surface of the grayish-red portions was 

 also granulated, of a faint lustre, and clouded. In these there appeared numerous, 

 more resistant, reddish-yellow spots, corresponding to tlie iimer portions of the lob- 

 ules. They were either isolated or gathered into small gi-oups. The interlobular 

 tissue was filled with a cloudy reddish fluid. In the softer portions of the lung the 

 pleura was smooth, transparent. The crit surface was smooth, shining, and here 

 and there provided with smaU diffusely dark red spots; resistant. On compression a 

 very fine foam poured out upon the cut surface. The bronchial lymphatics were 

 enlarged, their capsules reddened. 



In a second animal the lesions were the same, almost the whole 

 lungs hepatized. These animals had therefore suffered from an acute 

 pleuro-pneumonia, involving the pericardium in the first animal. 

 The yellow regions correspond to necrosed tissue, which, extending 

 to the surface, produces inflammation of the pleura. In cover-glass 



