BUREAU OF ANIMAL INDUSTRY 681 



preparations of the lung tissue the oval bacteria were found in large 

 numbers. The author infers from the lesions that the bacteria had 

 been aspirated into the finest bronchioles and alveoli and there pro- 

 duced pneumonia. They were also found in the pleural and peri- 

 cardial cavities. The remaining internal organs contained but few. 

 With portions of the hepatized lungs six mice, five guinea-pigs, two rab- 

 bits, two rats, two pigeons, and one fowl were inoculated. The mice and 

 rabbits died in the usual time, and presented lesions already described. 

 Three of the guinea-pigs died on the fourth, fifth, and eighth day 

 respectively. In the two first mentioned the subcutis and muscular 

 tissue at the point of inoculation (abdomen) were infiltrated with a 

 bloody, clouded liquid; in the third animal — an old one — an extensive 

 hemorrhagic and purulent infiltration was present. One of the 

 pigeons died on the third day. The point of inoculation in the sub- 

 cutis over the pectoral muscle was infiltrated with a fibrinous, puru- 

 lent mass, containing a few bacteria. These were very scarce in the 

 internal organs. One of the rats died on the seventh day with le- 

 sions similar to those of the older guinea-pigs. Very few bacteria in 

 the internal organs. With bits of lung tissue from another pig which 

 succumbed to the same infectious pneumonia the following animals 

 were inoculated: two rabbits, guinea-pigs, pigeons, and fowls, and one 

 rat. The rabbits died in one day, the guinea-pigs in two and five 

 days respectively after inoculation. The two pigeons, which had re- 

 ceived comparatively large doses, died in one and two days respect- 

 ively. The rat and fowls were not affected. 



The author also introduced pure cultures directly into the lung 

 tissue of a pig through the chest-wall by means of a hypodermic 

 syringe. The animal died in less than three days. On post mortem 

 examination the lungs were necrosed at the j^oint of inoculation; 

 there was severe and extensive pleuritis and pericarditis. Bacteria 

 were very numerous in the aiiected organs, but very scarce in other 

 organs. In another experiment a pig confined in a box was made to 

 inhale the spray of a liquid culture for several hours on two consecu- 

 tive days until 500'='= had been used up. The animal was killed eleven 

 days later, after having shown marked symptoms of lung disease. 

 The same mortifying pneumonia as that described was found at the 

 autopsy. 



Schiitz also describes a case in which there was a condition of the 

 lungs, lymphatic glands, and other organs closely resembling tuber- 

 culosis. Caseous degeneration of these structures was followed by 

 a gradual loss of strength, leading to death. In this animal there 

 was a caseous degeneration of the various joints of the posterior 

 limb, enlargement and softening of the lymphatics. The oval bac- 

 teria were present in large numbers in the caseous contents of the 

 giands. The effect upon the animals when inoculated with this 

 caseous mass was precisely the same as that produced by lung tissue 

 or cultures from former cases. 



The disease d isappears at the beginning of winter to reappear again 

 in the spring. The losses sustained by one owner from the disease in 

 a single year were very heavy, two hundred pigs having died. It 

 was found in regions a considerable distance apart, which led Schiitz 

 to infer that it was a widely distributed disease. 



The relation of hog-cholera to this disease.— A careful perusal 

 of this brief synopsis will convince even those who have only ob- 

 served the gross pathological lesions that are constantly met with in 

 hog-cholera, or who have read the post mortem notes as reproduced 



