484 



JiEPOllT OF THE COMMISSIONER OF AGRICULTUKE. 



Ptscrlbed to a failure in proparatiou. In faet, it is reasonable to antici- 

 pat(! that the time lost in importing- the va<;cine would be a serious ob- 

 stacle lo its application in this country, evcii if it could be shown, which 

 is by no means proved, that the same disease existed here, as long as 

 the present methods of kee]>ing the vaccine reuniin in use. 



(b) Vaccination ofinfjs. — The vaccination was uudertalien October 28, 

 twelve <lays after the lirst vaccination. Pigs Kos. 7G, 94, and 95', which 

 had received the first vaccine, were inoculated by a hypodermic injection 

 of about two and a half drops, which is the prescribed dose. In addi- 

 tion to these, two other pigs, Xos. 103 and lO"!:, received each about 2'^'' 

 of the same vaccine, one half into each thigh. Our object was to pro- 

 duce the disease, if possible, by a large dose, and compare it with the 

 disease pievaleut here. Kono of the anjmals beca-nc sicl:,*however. 

 The following table gi^x's the temperature of eacli vaccimited pig from 

 the day of the lirst vaccination to !N'ovember o: 



FIRST VACCIXATIOX, OUTODIiK llj. 



October 16. 

 O.'tobcr 17. 

 October 19. 

 Oclobor 20. 

 O.iobtT 21. 

 October L'-J. 

 October 'Z'i, 

 October 25. 

 0(:to)>er 2t) . 

 October 27. 

 October 28. 



Drtto. 



Ko. 70. I No. 78. No. Ot. No. D5. Xo. 1()3. No. 104. 



103 

 lO.'ii 



H':ii 

 103i 



lo^ 



1044 



102 



102i 



ion 



lUJ 



°F. 

 i02i 

 102 

 . lOJi 

 DicL 



<'F. 

 104i 

 lU4i 

 103i 

 104 

 10.>J 

 UKii 

 103 

 102.i 

 lOlii 

 104 

 103f 



lo:] 



1U23 



10:14 



m[ 



lo,;4 

 102.J 



lOo 

 103 

 ll)3J 

 103 

 1032 



1 oy. 



10!i 



104i 



One week after the second vaccination these })igs were i)enned with 

 two others which were aifected with swine plague of a very severe ty])e. 

 These animals had becji obtained from a place several miles from the 

 experimental station on Kovembcr 4, as no cases of swine plngue hj^d 

 been kept at the station since the summer of the same year. One of 

 these pigs, No. 105, died on the same day, the other, iN'o. lOtl, died in 

 the night between the tJth and 7th. The contact of the healthy with 

 the diseased did not extend over a period of more than two days there- 

 fore. 



The history of these vaccinated animals is briefly as follows: On the 

 morning of JSTovember 15, ]ngs jSTos. 95 and 103 were found dead. The 

 former had been twice vaccinated, receiving about 2"" of the first vac- 

 cine (at least ten times the proper dose) and about three drops of the 

 second. Pig N'o. 103 had received about 2«<= of the second vaccine only 

 (also about ten times th.e prescribed dose). Post mortem at 2 p. m., 

 temperature of the night previous and day 40^ to 50° F. There was no 

 distinct discoloration of the skin noticeabie. The superficial lymphatic 

 glands of the groin were tumefied and reddened. On opening the ab- 

 domen the small intestines were found studded witli whitish excres- 

 cences, caused by the attachment of echiuorhynchi. Delicate filaments 

 stretched across the coils of intestine and some serous effusion indi- 



