500 EEPORT OF THE COMMISSIONER OF AGRICULTURE. 



travasation on auricles of heart. The autopsy of 'So. 108 revealed a more 

 extensive ulceration and inflammation of the large intestine. The le- 

 sions elsewhere were similar to those of No. 107. In the spleen of both 

 animals the characteristic bacterium was found. No cultures made. 



In thecveniugofDecember SjtwopigSjNos. 120and 145, were fed with 

 four liquid cultures of the bacterium of swine plague and next morning 

 with five additional cultures, each culture being equivalent to lO'^'^. 

 These had all been tested on gelatine plates and found pure cultures of 

 the same microbe. The source of these cultures were pigs Nos. 96 and 

 97, the rabbit and mice inoculated therefrom. The cultures were mixed 

 with dry feed and were in this way readily consumed. December 10, 

 No. 145 was somewhat dull, and had slight diarrhea, continuing until 

 death, which occurred rather suddenly between 5 and 6 p. m. December 

 12, as it had eaten lieartily in the morning. It was examined early tlie 

 next day. No distinct discoloration of the skin ; superiicial inguinal 

 glands tumefied and slightly reddened. In the abomiual cavity, the 

 peritoneum covering the intestines was faintly reddened, the vessels of 

 the omentum distended and bright red. A small quantity of straw- 

 colored serum present. The surface of the liver was covered with bluish- 

 gray patches. The medulla of kidney, including tips of papillae, very 

 dark red; spleen dark, slightly enlarged; vessels of surface of heart 

 very much distended. 



In the stomach the mucous membrane of the fundus was, as usual, of 

 a very dark-red color. The severest lesions, however, and such as we 

 had not seen before, were found in the ileum and largo intestine. For 

 about 3 feet from the valve the entire mucosa of the ileum was necrosed, 

 stained yellowish, and could be scraped off with the scalpel. The ccccum 

 appeared as if macerated ; the mucous membrane came away iii toto. In 

 the lower part of the large intestine, the complete necrosis was gradually 

 replaced by a dark-red membrane dotted with yellowish ulcers about one- 

 fourth incii in diameter and not more than half an inch apart. Finally, 

 in the rectum ulceration was absent. The affected intestine was so much 

 thickened that it tailed to collapse when cut open and contents removed. 

 In this case the local effect of the ingested bacteria had been tremendous, 

 overshadowing the lesions of the remaining viscera. Even the lym- 

 phatic 'glands, almost invariably and severely diseased in the preced- 

 ing cases were but moderately inflamed; those of the mesentery, how- 

 ever, were very much enlarged. The other animal. No. 120, died one 

 day later. The temperature was but slightly elevated until December 

 12, when it reached 108° F. Great debility supervened until death, De- 

 cember 14. In this animal superiicial inguinal glands were fouud en- 

 larged, the cortical portion gorged with blood. Spleen enlarged, dark, 

 friable. A few ecchymoses on endocardium and epicardimn. Isolated 

 lobules of the lungs dark red, hepatized, showing here and there ex- 

 travasations under the pleura. DoLli kidneys much swollen, surface 

 dark red, numerous extravasations under the capsule. Oukscciion the 

 cortical portion dotted vrith closely-set dark points, medullary i^ortion 

 also congested. Lymphatic glands of mesentery very large, those of 

 mesocolon gorged with darlc blood. The mucosa around the ])ylorus 

 and on its valve colored deep purple, the inllamraation extending for 

 some distance into the duodenum. The mucosa of the small intestine 

 (containing a lew si>ecimens of ascaris) was not diseased except near 

 the iIeo-ca3cal valve, where a small area was covered with punctiform 

 extravasations. The caecum and upper third of the large intestine were 

 the seat of extensive ulceration. The yellowish, superficial ulcers were 



