BUREAU OF ANIMAL INDUSTRY. 519 



larger dose had no marked discoloration of the sMn. This animal died 

 at the cud of the third day. The post mortem, made on the following 

 day, gave, in brief, the following : Bluish discoloration of the skin, 

 serons offiisions into the peritoneal and pleural cavities. More or less 

 reddening of the mucous membrane of stomach and intestine, large and 

 small, with occasional hemorrhagic spots. Bacilli present in the serous 

 exudates, in the blood, liver, kidneys, and lymphatic glands in moderate 

 number, very abundant in lungs and spleen. The other animal died a 

 day later. The lesions were very much the same, excepting that tberc^ 

 were hemorrhagic spots and patches beneath the endocardium of the 

 left heart. 



Tlie same investigator also prodiiced the disease in mice, pigeons, 

 and a rabbit. In the latter animal it assumed t]i« form of a local ery- 

 sipelas at tirst, leading linally to deatli. In a more recent article {Arch. 

 f. tciss. tupraJit. ThierheWmnde, 18SG, XII, 30-52) he gives tlie autopsy 

 notes of seven pigs which died of rongct. In summing up these cases 

 he says (page 44) : , 



In all aoimals tliere wero diseased tlie stomach, the intestinal canal (the solitary 

 follicles and Peyer's patches), the mesenteric glands, the spleen, liver, kidneys, the 

 heart, and the skin. 



In the notes of individual cases we observe that the skin was invari- 

 ably bluish red. In the intestine ulcerations were absent, the large 

 intestine being nearly normal in every case. In the blood and spleen 

 the fine rongct bacilli were found in all cases on cover-glass prejjara- 

 tions. 



Tlie latest and most exhaustive work on rongct, in connection with 

 extensive exiieriments with Pasteur's vaccine, is that of Lydtin and 

 ychottelius. {Op. eit.) 



They find that animals that vsuccumb to vaccination present lesions 

 markedly dillerent from those which die of spontaneous infection. We 

 quote from page 21 concerning the intestinal lesions in spontaneous 

 cases (Lydtin): 



The solit.ary follicles, as well as Peyer's patches, appear quite distinct, especially 

 near tlio posterior extremity of the small intestine. Sometimes they hav^e dropped 

 out so that real intestinal ulcers, especially in the region of the ileo-ctecal valve are 

 l>resent, but only in small nnmiier. The contents of t!>o large intestine are either 

 solid, or if this be not the case, blockish, tluid, resembling Avagon grease. The mucous 

 meml)rane is also swollen, diffusely reddened in spots or patches. In many places 

 it seems corroded, brownish, and deprived of its epithelium. 



There is no mention of ulceration in the large intestine. In the ani- 

 mals which died from the elfects of inoculation with Pasteur's vaccine 

 (0 out of 119) Dr. Schottelius determines (p. 206) that "the mucosa of 

 the intestinal canal is not altered. It is covered with intestinal mucus 

 and normal feces and is pale, with the exception of a faint reddening 

 near the ileo-caical valve." 



In the autopsy notes of a pig infected in the natural way the sanu' 

 author (p. 209) describes an extensive swelling and ulceration of Peyer's 

 ])atches and the solitary follicles of the lower portion of the ileum : 

 *' Such ulcers are also found in the upper portion of the largo intestine, 

 l)roceeding from solitary follicles, hence correspondingly smaller and 

 circular." AVe have already called attention to the fact that in swine 

 plague the ileum is rarely implicated, and only in the severest cases, and 

 that the ulcerations in the large intestine are not confined to lymphatic 

 follicles, but may involve the entire surface. This latter fact was pointed 

 out by Klein. He also states that he saw in but one case out of fifty 

 two deep ulcers in the ileum. 



