GLANDERS AND FARCY. 453 
wound is sufficient to inaugurate the acute course or a rapid progress of 
the morbid process. 
2. If glanders has been communicated by a direct introduction of 
glanders-matter into a wound, or a direct contact of the contagion with 
the blood. The greater the quantity of glanders-matter introduced the 
more concentrated the contagion inoculated, or-the larger the wound 
the more acute or rapidly progressing and spreading is usually the 
morbid process of the communicated disease. 
3. If the constitution of the animal has been weakened, or if the 
vitality of its organism has been seriously impaired either by glanders 
itself or by any other disease, the course of glanders, although natu- 
rally slow or chronic from the beginning, is usually changed to an acute 
one as soon as the morbid changes have become sufficiently important 
and extensive to weaken essentially the constitution of the animal, and 
to cause a profuse infection or spreading of the contagion through the 
lymphatics in the animal organism. ‘Toward its fatal termination 
glanders, therefore, always changes its course from chronic to acute. 
Unlike most other diseases it commences chronic and ends acute. 
4, Exposure to wet, cold, and inclement weather, catching cold, hard. 
work, close, dirty, and ill-ventilated stables, unhealthy food, &e—in 
short, everything that is calculated to produce an injurious influence 
upon the organism, or is calculated to impair the health of the animal, 
has a tendency to accelerate the morbid process, to change the chronic 
course of glanders to an acute one, and to hasten the outbreak after an 
infection has taken place. 
The morbid process of glanders is accelerated and caused to spread 
more rapidly if the latter becomes complicated with an inflammation, 
or with any very feverish or very typhoid disease. The morbid pro- 
cesses of glanders and inflammation increase each other reciprocally. 
The inflammatory process adopts, to a great extent, the nature and 
characteristics of glanders, and the morbid process of the latter disease 
becomes blended with the former, and assumes the attributes of an in- 
flammation. In either case all the symptoms become very violent, and 
the morbid process progresses and spreads very rapidly, particularly © 
* in those tissues which are in a state of inflammation. Ulceration, too, 
becomes extensive in a short time, and the lymphatics, by absorbing 
the deleterious matter, seem to spread the contagion and the elements 
of glanders rapidly through the whole system. - If the original disease 
is glanders, farcy will also make its appearance within a short time; 
and vice versa, existing farecy will soon be complicated with nasal and 
pulmonal glanders of am inflammatory character. The exudations pro- 
duced by an inflammation which has assumed the nature of glanders 
are always very deleterious and corrosive and destroy like a caustic the 
tissues with which they come in contact. The morbid changes effected 
by such an inflammation resemble those of a malignant diphtheria. In 
extreme cases the morbid process may become so violent as to cause 
the neoplastic process, characteristic of glanders, to be superseded 
by immediate destruction and mortification. In such a case profuse, 
diphtheritic ulceration and destruction of tissue take the place of the 
neoplastic production of glanders-cells and their subsequent decay. 
The glanders-cells are destroyed (decay or perish) before their forma- 
tion has been completed, consequently are absent. 
That a direct and abundant introduction of glanders-matter into a 
wound, or a direct contact of the contagion with the blood, is well cal- 
culated to produce an acute form of glanders, or sufficient to inaugurate 
a rapid progress of the morbid process, is probably best illustrated by a 
