: GLANDERS AND FARCY. 459 
and 4.) Such a production or development of glanders-cells just de- 
scribed can take place in young or undeveloped and incipient epithe- 
lium-cells, because round giant-cells filled with nuclei and small round 
cells are formed frequently in the deeper or youngest strata of the epi- 
thelium. (Fig. II, No. 5.) 
Wherever such a neoplastic growth is making its appearance the pro- 
cess is always essentially the same. The original nuclei of the primary 
epithelium-cells and connective tissue-corpuscles increase in size, and 
new nuclei are formed within the external membrane, or envelope, of 
the primary cells. These nuclei are transformed into small round cells, 
which are liberated by the decay of the old mother or brood-cells, and 
constitute what is called daughter-cells, and grow larger. This growth 
and development constitutes a characteristic peculiarity of the large 
round glanders-cells, which distinguishes the same from otherwise simi- 
lax granulation-cells, matter-corpuscles, and tubercle-cells, because the 
latter, during their whole existence, remain unchanged at their first 
stages of development. Although young glanders-cells are small, and 
large ones old, the difference in size does not depend exclusively upon 
the age of the cells. Other growth-promoting and growth-retarding in- 
fiuences must be existing, because some cells grow faster than others, 
and some do not seem to grow at all. Under certain circumstances only 
small cells can be found, which are not different from common matte1 
corpuscles, and in other cases a great many large ones, sometimes of an 
extraordinary size, present themselves. If the morbid process is a vio- 
lent or a very rapid one, the glanders-cells are always small; rapid 
development and a fluid intercellular substance constitute the agenciés 
which deprive the cells of their ability to grow, or cause them to remain 
small, and of a somewhat uniform size. Consequently, in all those cases 
in which the morbid process of glanders is blended from the beginning 
with more or less inflammation and exudation, the glanders-cells will be 
small and numerous; and as the imflammatory exudations destroy and 
dissolve the intercellular substance, the latter and the exudations them- 
selves will constitute a fluid in which the glanders-cells are kept sus- 
pended. The glanders-matter thus formed does not present, under the 
microscope, any characteristic differences from any other matter or pus. 
A production of glanders-matter and of numerous small glanders-cells 
is common if the neoplastic process has its seat in the subcutaneous and 
intermuscular connective tissues consequent in farcy.. In all those cases, 
however, in which glanders presents itself as a chronic disease, free from 
any complications with inflammatory processes, &c., whatever, in which 
the formation of the glanders-cells is a gradual and slow one, and in 
which the intercellular substance is not destroyed and dissolved, the 
glanders-cells will grow to a certain size, and young cells with delicate 
contours and large, bright nuclei, older and larger ones, and very large 
pe re with dark-colored nuclei and granulated contents, will present them- 
selves. 
The vitality of the neoplastic products ot glanders is limited, but dif- 
fers considerably according to circumstances. The small, rapidly pro- 
duced, and therefore numerous, cells, suspended in a dissolved intercel- 
lular tissue and exudations, are similar in every respect to matter- 
corpuscles ; the same not only do not grow, but shrink and decay very 
soon. If the intercellular substance does not decay, but retains its 
original connective properties, the glanders-cells not only grow larger, 
but also a great deal older, than matter-corpuscles or tubercle-cells. This 
vitality will be the greater the larger the space or the greater the amount 
of the connective intercellular substance between the single cells. Their 
