GLANDERS AND FARCY. 465 
very much swelled or just breaking, and others decayed and discharg- 
ing their granulated contents and large nuclei, and a connective inter- 
cellular substance which gives the whole tumor its continuity and a cer- 
tain degree of solidity, constitute the principal components. The softer 
glanders-tumors, similar in consistency to a sarcoma, are composed 
mainly of round cells, while the firmer or more solid ones consist prin- 
cipally of spindle-shaped cells, and contain comparatively few round 
cells imbedded in the intercellular substance, which latter is here and 
there fibrous and solid, and thereby the cause of the greater firmness. 
The presence of both kinds of cells, spindle-shaped and large, round 
ones, proves that connective-tissue corpuscles, as well as epithelium ele- 
ments, contribute to the formation of pulmonal glanders-tumors. The 
retrogressive metamorphosis proceeds, according to the observations of 
Gerlach, in two different ways. Sometimes all components of the glanders- 
tumor, the intercellular substance as well as the glanders-cells, undergo a 
process of decay which proceeds either from one center—if the tumor is a 
simple one—or from several centers simultaneously, ifthe tumor is a compli- 
catedone. Inthe former case the whole tumoris changed to one cavity with 
cheesy contents, but in the latter two or more larger or smaller cavities, 
corresponding to the number of the original tubercles or tumors, are 
produced. The contents of the same present also a cheesy appearance. 
Sometimes, however, the whole process is different. The round-cells 
decay and are absorbed, and an excessive growth or production of con- 
nective tissue is taking place. The tumor becomes harder and firmer, 
and assumes finally the characteristics of a fibroid growth, which con- 
tains interspersed in its tissue a few round-cells, and may not undergo 
any further changes for a long time. Such fibroid tumors correspond 
to the fibroid cicatrices which occur frequently in the mucous membrane 
of the septum, and are found not seldom if the morbid process has been 
a very Slow or chronic one. If glanders is acute or complicated with 
other morbid processes which accelerate its progress, such hard and 
firm fibroid tumors or cicatrices are never formed. On the contrary, 
the glanders-tumors decay rapidly, often before the same have had time 
to assume definite shape and form. ' 
Glanders-ulcers or abscesses are produced if the intercellular sub- 
stance of the tubercles undergoes dissolution. Dissolved intercellular 
substance and decayed and decaying glanders-cells constitute the matter. 
The process is about as follows: 
Farcy-ulcers in the subcutaneous connective tissue—The development 
or the growth of a farcy-tumor is always attended with some local in- 
flammation in the surrounding tissues. A violent proliferation begins 
in the center of the tumor, and numerous small round-cells which can 
scarcely be discriminated from matter-corpuscles are produced. The 
inflammatory process furnishes a sufficient quantity of exudation to 
loosen and to envelope the round-cells almost immediately after the 
same have been produced. Some white blood-corpuscles may become 
intermixed, but the same must be regarded as strangers, because a very 
large majority of the cells suspended in the fluid exudation are the pro- 
duct of the proliferous process. So it may happen that a farcy boil or 
tumor shows fluctuation, and contains matter within a few days, or is 
changed to an abscess much sooner than a common boil. The matter 
of a farey-ulcer does not exhibit any distinctive difference from other 
pus except in so far asit possesses infectious qualities. Almost as soon 
as a farey-boil has been changed to an abscess, or contains matter, the 
nearest subcutaneous lymphatics commence to swell to plainly visible 
chords or strands, and in their course not seldom new boils are formed. 
” 
TY 
oo) ACR 
