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- ence, symptoms closely resembling those of cinchonism result. | These are fullwees Mi 
able to trace the toxic manifestations. Along with an intensification of the symp-_ 
_ tomsalready mentioned there are ptosis, deafness, strabismus, mydriasis, disturbance 
- tion seems to be characteristic, it being both quickened and deepened, often sighing, 
| Sweating is usually very free, and the urine early becomes albuminous. Various 
-- bed-sores at points subjected to pressure, and transitory dark-colored maculze om! © 
acid, although there is scarcely one instance which is beyoud doubt.* In certain 7 
- of its influence. 4 
- upon a decision of the consulting committee of hygiene that its con-_ 
port to other countries where its use is allowed. 
el 
A Spa aig Griatcd . ’ 3 ar ic 3 a D : 
When salicylic acid is given to man in doses just sufficient to manifest its pr 
of the head, withroaring and buzzingin the ears. After larger doses, to these sym 
toms are added distress in the head or positive headache, disturbances of hearing 
and vision (deafness, amblyopia, partial blindness), and excessive sweating. Accord- 
ing to Reiss (Berlinger Klin. Wochenschrift, 1875, p. 674) decided fall of temperature, — 
without alteration of the pulse, also occurs; but this is denied by other observers, 
The actions upon the system of the acid and of its sodium salts (also ammonium salt, . 
Martenson, Petersb. Med. Zeitschrift, 1875, p. 243) appear to be identical, and, as 
several cases of poisoning with one or other of these agents have occurred, we are 
of respiration, excessive restlessness passing into delirium, slow laboring pulse, olive 
green urine, and involuntary evacuations. In some cases the temperature has re- , 
mained about normal, but in others has approached that of collapse. The respira- 
local evidences of vaso-motor weakness may supervene, such as rapidly-appearing ~ 
various parts of the body. In several cases death was probably produced by the ~~ 
cases the mental disturbance has been strangely prolonged, lasting for eight days, - 
In some instances it is cheerful, in others melancholicin type. Itis stated thatupon | 
drankards the acid acts very unfavorably, violent delirium being an early symptom 
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cases of acute rheumatism is given as one dram (3.9 grams) in twenty- — 
four hours. It is excreted chiefly by the kidneys and may be de- 
tected in the urine very soon after its ingestion. Authorities in’ 
therapeutics warn practitioners of medicine against its administra-  ~ 
tion to patients whose kidneys are known to be diseased, and of late Les 
years the opinion has been growing among physicians that it hasa 
very irritating action upon these organs, many preferring the alkaline — 
treatment of rheumatic fever on this account. 5 le 
am USE AS A PRESERVATIVE, \ a 
The “‘salicylic-acid question,” as it is called, has received a great. ¥ 
deal of attention for several years in Hurope, and much has been. ~ 
written, pro and con, on the question of the propriety of its use as ae 
preserving agent in articles of food and drink. In France its useas © 
@ preservative in any form of food or drink was forbidden by minis- —_ 
terial decree on the 7th of February, 1881. This decree was based | ” 
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ye. 
stant use was dangerous to health. 
In Germany its use is prohibited, except in beers intended for ex-" 
Its prohibition in France called forth a great deal of opposition, 
and experiments were made and published which were intended to — ih 
show that its constant use in small doses exerted no injurious in-\" 
fluence upon the system. Kolbe himself made experiments upon” ~ 
himself and his assistants by taking doses of .5 to 1.0 gram daily for ae 
*In the case recorded in the Virginia Medical Monthly, June, 1877, forty-eight gh 
grains.of the acid were taken in four hours. Thesymptoms were violent vomiting, it 
headache, total unconsciousness, with stertorous breathing, Death occurred forty 
hours after the first dose, re tis) 
i 
