bit, about one-half centimeter cube, was torn up with’ flamed forceps in a flamed 
watch glass containing some sterile beef infusion, and the turbid fluid injected be- 
_ neath the skin of the thigh. Thesyringe used was an ordinary hypodermic syringe, 
-__ earefully disinfected by 5 per cent. carbolic acid above and below the piston for one- 
_. half hour, both after and before use, and each time thoroughly rinsed in boiling 
__. water. As hog cholera bacteria are destroyed by a 1 per cent. solution of carbolic 
acid in less than ten minutes, and by a momentary contact with water near the boil- 
‘ing point, the disinfection was certainly all that could be desired. This method was 
_ regarded as less open to criticism than the insertion of bits of tissue under the skin. 
We still stand in need of a syringe which can be disinfected without much trouble, 
as the above method is extremely tedious. Both kinds of syringes devised by Koch 
. are unsatisfactory. The joints formed by the glass barrel and the metal cap in the 
- syringe, in which the propelling force is air, were found to leak in five out of six 
samples. 
__ order to get an idea of the approximate number and the kind of organisms present. 
‘In every case the portion of lung tissue from which the inoculations were made 
_ had been transferred to sterilized bottles at the autopsy and protected from acci- 
dental contamination as carefully as possible. 
The igh percentage of mortality in epizootics of hog cholera like 
the foregoing is the first thing to claim our attention. Out of 139 
animals not less than 100 perished in the brief space of two months, or 
over 70 per cent. Asno disinfection was resorted to, and no isolation 
of the healthy attempted, if is difficult to say what number could 
have been saved. At any rate the above figures indicate the mor- 
tality of this disease when left to itself, and it shows that nearly all 
young animals, such as weigh between 50 and 100 pounds, are sus- 
ceptible to this disease. : 
Most of the animals died rather unexpectedly. Only a compara- 
tively small number were bagasse! diseased some time before death. 
Since in many there was more or less ulceration in the large intestine, 
-it indicates that animals may be in a very bad condition and become 
i a source of infection for others without showing it. 
The swill feeding has already been mentioned as a probable cause 
- of the cirrhosis of the liver observed in so many of these animals. 
This organ was tough and imparted a gritty sensation to the hand 
whencut. Theparenchyma was softened and degenerated. It seems 
| reasonable to suppose that this chronic malady may have made the 
~ herd far more susceptible to the disease, and more especially to the 
acute hemorrhagic type. 
Hemorrhagic lesions.—At least one-third of the cases examined’ 
showed lesions of a hemorrhagic character. The most common 
was an infiltration of the cortical portion of lymphatic glands with 
blood; sometimes the entire gland appeared hemorrhagic on section, 
- As regards the relative frequency of this condition, the bronchial, 
_» posterior mediastinal (aortic), and inguinal glands stand first; next 
the retro-peritoneal, meso-colic glands, and those in the lesser curva- 
ture of the stomach. The mesenteric glands were rarely affected. 
/ 
_ Accompanying this condition of the lymphatics is usually a very , 
_ large spleen, its great size being simply due to an engorgement with 
blood. 
Next in frequency were the hemorrhagic lesions of serous mem- 
branes in the form of punctiform extravasation, larger ecchymoses, 
* 
c 
and very rarely of collections of blood infiltrating the muscular lay- 
ers beneath the serous membrane. These extravasations are most 
_ frequent on the auricles and ventricles of the heart, under the serosa 
of the large and small intestines, beneath the pulmonary pleura, and 
From the fluid injected into rabbits either plate or roli cultures were’ made, in — 
