2 itil iianwiabas ‘The desquamation. and p shOLReCyaEG 
the alveoli and smallest air tubes until they are occluded by 
me casts described. . >. X 
Of the 19 animals of the same herd 17 were ‘found with colle 
ee 8 with lobular broncho-pneumonia; more than one-half, the 
oe had some defect of the lungs. ; 
“It might be questioned whether such lesions as those of bronch 
Pe aeionin are not due to swine plague bacteria since they. closel; 
resemble the appearance found in many swine-plague lungs. — 
‘SRS ~ question is effectually disposed of by: the inoculation of lung tissi 
into rabbits. From 16 lungs, 16 rabbits were inoculated. Of these, 
8 lungs were involved in simple collapse, 8 in broncho-pnenmonia, 
Of these 16 rabbits 4 survived; the remainder died of hog cholera, — 
oe ‘ OF the 4 survivors 3 had been inoculated from. ‘collapsed lung tissue; 
1 from a broncho-phe OMe It is interesting to note that ‘of thes 
- rabbits, 1 died in six days, 4 in seven days, 3 in eight days, 2 in ten 
. days, 1 in thirteen, and a in fifteen days after inoculation. ‘Plate. 
~ cultures from the corresponding bit of lung tissue showed a variable | 
number of colonies almost invariably non-liquefying, and i in man, 2 
cases identified as hog cholera bacteria. : 
These facts prove that in hog cholera the specific bacteria will find 
_ their way to any diseased portion of lung tissue and there multiply 
to a certain extent. In one case plate cultures from a bit of norma 
- Jung ns showed but one or two colonies, while a bit of collaps 
‘tissue from the same lung showed a large number. There is n 
doubt that the slight exudate and feeble circulation in collapse, and 
the abundant partly cellular and partly mucous or fibrinous exudate 
into the air spaces in broncho-pneumonia, furnish a favorable nidus 
for pathogenic bacteria. These may have been carried there by the 
_ blood, or they may have been introduced from without. If the fabian hay 
3 supposition prove true, and there are no valid objections to it, dis- 
~~ eased lungs in hog cholera may not only become the means of dis- a 
seminating the disease through the mucus and expired air, but they ai 
may become the channel, the weak spot, through which ‘the virus : 
“dt enters the organism. a 
> > To elucidate this question if boestble, the following instructiveex- 
.): periment was made: a 
aR Two pigs (460, 461), about ten weeks old, received into the right — 
e lung, December 21, 3° each of a beef infusion peptone culture, - 
metra.“ two days old, inoculated frond a single colony growing in a roll cult-) ~ 
ne ure. This had been made from a bit of spleen tissue from pig No. 46 eae 
Peres of the outbreak described in these pages. There were about fifty — 
/- golonies inthe tube, all alike. To test the culture a rabbit received ~ 
eS - at the same time one-ninth® subcutaneously in the thigh. It died 
Lean in five days. The spleen was much enlarged, blackish, ‘friable. and 
nae contained hog c aholera bacteria. A roll culture contained numerous — 
colonies after two days. : 
No. 460 became very weak in its hind limbs in less than a week: 
; respiration short and quick; bowels relaxed. It was was found dewid 5 
coe onthe ninth day. ae a 
tes Superficial inguinal glands normal. Petechiz in the slight deposit of fatty tissue 
ee beneath peritoneum of abdominal muscles. Spleen about’ 12 inches long, 14 wide, — 
and three- -four ths inch thick at the hilus, blackish, friable. A few petechize on cor- “yt 
tex of left kidney, one cyst the size of a large pea in medullary portion. Large i 
number of Beat hemorrhages in connective ‘tissue around pelvis of right kidney. 
eee Two small urinary cysts not showing on surface. Glands i in lesser omentum en- we 
