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‘yertebr were still normal. 
_ The coior of the hepatized regions was grayish red to reddish yellow, sprinkled | 
with closely set yellowish white spots from 4%" to 5™™ in diameter and slightiy proiw- 
inent. On section the same appearance present: throughout the diseased lung 
tissue. The recently affected lobules are either uniformly and deeply reddened or ' 
‘sprinkled with a large number of very minute whitish points. Odor slightly putre- 
factive. , 
- The yellowish white masses were firm and-cut with a smooth surfice. Micro- 
‘scopic examination showed them to be made up of broken down cells, among 
which were immense numbers of various kinds of bacteria. -These lesions were — 
evidently produced by the same cause that we had studied in western outbreaks. 
There was but one way to speedily isolate the specific microbe from the mass of 
other microbes which were living in the dead cell masses. Three mice were in- 
* oculated by placing beneath the skin of the back bits of lung tissue from the re- 
cently diseased areas. A rabbit was inoculated in the thigh in the same way by 
making an incision through the skin, which had been disinfected with 1 per cent. 
mercuric chloride, introducing a bit of lung tissue and drawing together the in- - 
cision with a stitch. 
_ The rabbit died within 24 hours. Very slight purulent envelope about bit of 
tissue. No other reaction locally: Nearest lymphatic hemorrhagic.: In it,as well 
as in blood from the heart, spleen, and liver, immense numbers of the polar 
stained bacteria. Cultures in gelatine and liquid from blood pure. Two mice died 
on the third day. Bacteria present insmailnumbers. The third died on the fourth 
day. Immense numbers of the same bacteria in blood from heart. Pure cultures 
from the latter organ were obtained from each mouse. 
Pig No. 405 (bit of lung tissue). 
rabbit, Feb. 18 3 mice, Feb. 18 
died Feb. 19 died Feb. 21, 22 
(swine plague bacteria only in cultures) cultures from blood contain only swine plague bacteria 
One of the most pronounced cases of this disease died February 21, and was ex- 
e > 
amined on the following day. 
No. 407. Pig of medium size, white; skin of abdomen, chest, neck, and back 
deeply reddened. Fat abundant, slightly reddened along the linea alba. Superfi- 
cial inguinals slightly enlarged; spleen dotted with elevated blood-red points. Liver 
very dark. Stomach and duodenum normal, the latter bile-stained. In ileum 
Peyer’s patches are visible as groups of small, dark dots: no swelling. Mucosa of 
cecum and upper colon of a dirty, blackish color, probably pigmented.- A few 
hzematomata beneath mucosa. Besides the diffuse pigmentation the mucosa is 
sprinkled with isolated or confluent masses, about one-eighth to one-fourth inch in 
diameter, of a dirty grayish-yellow color, loosely adherent to the membrane. When 
pulled away a slightly depressed surface is exposed. Much of this mass can be 
easily removed by simply moving the scalpel over it. There are several ulcers in 
the czecum with decided loss of substance. The patch of mucous glands at the base 
of the valve is also converted into an ulcerated mass. Lymphatic glands in abdo- 
men slightly swollen and reddened. Kidneys deeply reddened to tips of papille. 
On opening the thorax the lungs did not collapse, and a rather disagreeable odor 
was perceived. Asin No. 405, the ventral and cephalic lobes of both lungs were 
consolidated. The hepatized regions were-very hard to the touch, bright red, with 
yellowish points sprinkled in regularly, indicative of broncho-pneumonia. (See 
Plates I, 11, III, Fig.1.) The right lung was adherent to chest wal! along the hepa- 
tized portion. A whitish, spongy membrane was interposed, about 3" to 5"™ thick, 
inclosing a small quantity of turbid liquid. On removing the lung the membrane 
remained adherent to pulmonary pleura and was removed with difiiculty.. A por- 
tion of the diaphragm was also firmly attached. The left lung adhered firmly to 
the costal wall in two places where it was consolidated. The costal pleura was 
deeply reddened, owing to the injection of a close net-work of minute vessels. Tra- 
chea and bronchi filled with whitish foam. 
On section, the consolidated region is sharply but irregularly marked off from 
the normal tissue, very consistent and slightly elevated. The color varies froma 
bright red (recent) to a grayish red. In all the minute grayish points are present 
from 1™™ to 2™" in diameter, about the same distance apart, and of a hazy outline. | 
The smaller bronchi are filled with a purulent fluid. In the surrounding lobules 
principal lobes. Those portions resting against the — 
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