Matty 
BUREAU OF ANIMAL INDUSTRY. 501 
No. 372 had been exposed in a pen, infected with hog cholera, to the lung dis- 
ease. It had therefore been exposed to two different diseases. It began to grow 
weak and stupid, eating very littie until death, on March 20, more than a month 
after the earliest symptoms of disease. This animal was found with extensive lung 
disease, while its internal organs contained hog cholera bacteria, as the following 
remarks indicate. 
Animal with moderate amount of fat. Stomach bile-stained. Gall bladder filled 
with a thick prune-juice colored mass. Beginning sclerosis of liver. No intes- 
tinal lesions. Lwngs.—Right ventral and left ventral lobes almost entirely solidified. 
Median ventral and cephalic border of right principal lobe solid, exceedingly hard 
to the touch ; pleura covering itthickened. On section the lung tissue is found cons 
verted into a grayish, homogeneous, caseous mass. In left principal lobe a mass 
of tissue about 2 square inches in extent is solidified, some lobules being caseous, 
others still red. In the hepatized ventral lobes there are many lobules converted 
into a yellowish-white, homogeneous mass, almost cartilaginous. The small 
bronchi exude a glairy purulent mucus. 
In the recent lesions bacteria few in number ; in the caseous masses immense 
numbers, nature not determinable. 
Liquid cultures from blood and spleen contain not swine plague but hog cholera 
bacteria. A gelatine culture from the blood contains the same bacteria. A rabbit 
inoculated subcutaneously with one-fourth’ of a beef infusion culture died on 
the sixth day with greatly-enlarged spleen and coagulation necrosis of liver. In 
both organs the injected bacteria were present in large numbers. Of two mice 
inoculated with lung tissue one died next day ; no examination made. Unfortu- 
nately no rabbit was inoculated from the lung tissue. 
Pig No. 372, died March 20. 
blood lung 
2 mice March 22 
one died March 23 
gel. cult. b. i. cult. other not affected 
hog cholera bacteria 
plate cult. 
gel. cult. 
b. i. cult April 1. 
rabbit April 2 
died April 8 
(hog cholera) 
Pig No. 397 illustrates well the existence of two diseases in the same animal, the 
hog cholera bacteria being obtained from the spleen, the swine plague germs from 
the lungs. This animal was fed with the hepatized lung of pig No. 378 on March 
24, and three days later with lung tissue from pig No. 359. In a week it became 
feeble, especially in the hind limbs, dull, without desire for food. April 12 diarrhea 
set in and it died next day. Post-mortem examination revealed extensive disease 
of the lungs and large intestine. The animal had contracted swine plague first; 
upon a disease hog cholera was grafted, which probably was the immediate cause 
of death. 
Slight discoloration of skin on ventral aspect of body. Superficial inguinal glands 
_ enlarged, cortex infiltrated with blood, meduila dotted with petechiz. Some fibrils 
of coagulated lymph across coils of intestines; small quantity of serum present in 
abdomen. Mesenteric glands very large, deep red. On section almost entirely in- 
filtrated with blood, excepting a few patches of the medulla, which are homo- 
geneous yellowish white; glands of meso-colon dark red. Spleen greatly engorged 
with blood, friable. In liver the connective tissue increased in quantity, paren- 
chyma softened. 
In thorax the right pulmonary pleura covered with a thin film of exudate. Con- 
siderable yellowish serum in both pleural sacs. The cephalic and ventral lobes and 
the ventral portion of principal lobe hepatized. The hepatization presents that 
peculiar grayish-mottled appearance on a deep-red ground; trache filled with 
whitish foam. Digestive tract.—Stomach filled with a turbid yellowish liquid, 
mucosa in general bile-stained, in fundus deeply reddened. In the large intestine 
the mucosa is uniformly and very densely sprinkled with dark-red points (extra- 
