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502 REPORT OF THE COMMISSIONER OF AGRICUL 
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vasated?). A dirty, yellowish, projecting ulcer on base of valve. Four or five of | p! 
the same character, three-eighths to one-hal! inch across in caecum and upper colon, 
In this animal the brain and spinal cord were luid bare. A few punctiform recent f 
extravasations, chiefly in the white matter of the cerebellum. Fee 
With a bit of lung tissue two rabbits wereinoculated—one beneath skin of thigh, 
another in the ear. Both were found dead within forty hours after inoculation; the ‘ 
bacteria of swine plague present in spleen and liver in large numbers, and obtained 
pure in cultures. : 
From the. spleen, pleural, and peritoneal exudate the hog cholera bacteria were 
obtained pure. They were very scarce in the pleural exudate, however, as two out 
of three liquid cultures remained sterile. Two mice inoculated from the spleen =~ 
culture were dead on the sixth day, both of hog cholera from the injected cultures, — 
Pig No, 397 died April 14. 
lung tissue | 
| spleen peritoneum pleura 
rabbit (subeutis) April 15 rabbit (ear) 
both dead April 17 cultures contain hogcholera ~ 
i bacteria only ‘ 
(swine plague) 2 mice Apr. 15 
died Apr. 20 
(hog cholera) 
Number 396 is another interesting case of lung disease complicated with hog 
cholera. This animal had been fed February 22 with portions of the spleen and 
large intestine of number 407, which has been dwelt upon in the preceding pages. 
A few days after feeding it began to show signs of disease by growing weakness, \ 
especially marked in the hind limbs, no desire for food, and a slight diarrhea. A 
month after feeding, constipation set in, while the weakness of the hind limbs was 
very marked, bordering on paralysis, and anorexia continued. In the seventh week 
diarrhea again set in: the animal was unable to rise and died April 18, nearly twc 
months after feeding. It was found with severe and extensive lesions of the lungs 
‘and large intestine. (See Plate IV.) . 
Digestive tract.—Stomach filled with food; normal. Large intestine, excepting 
rectum, ulcerated. Ulcers surrounding valve and forming a confluent mass in 
cecum. In upper colon there are masses of exudate from one-eighth to one-fourth 
inch in diameter, at least 20 to a square inch (Plate IV, Fig. 2); lower down fewer 
in number. They are roundish, convex, brick-red masses which may be easily 
lifted from a raw, slightly depressed surface; every one is surrounded by an injected 
border. The mucosa itself is of a bluish-green color. 
Langs.—Right ventral lobe firmly and closely adherent to chest wall by a con- 
tinuous sheet of fibrous tissue. This lobe feels like a bag filled with hard round 
bodies. On section it is found filled with whitish homogeneous masses resembling 
hard cheese (Plate IV, Fig. 1) embedded in bright-red, hepatized lung tissue. Left 
cephalic lobe in the same stage. The remainder of the left lung contains groups of 
lobules recently hepatized. Cavities of heart as in preceding cases. 
Two rabbits and two mice inoculated in the ears with lung tissue without any 
result. 
Gelatine cultures from pleura remained sterile, A culture from the spleen con- 
tained several forms, one of which resembled the hog cholera bacterium. After 
isolating this, two mice were inoculated from a pure culture. Both died in seven 
days with lesions characteristic of this disease. 
The hog cholera germs were therefore present in this animal. The swine plague 
germ was not isolated, perhaps because the germs were too few. In such cases in- 
‘oculation on the ears of rabbits seems to fail. since only a minimum quantity of lung 
tissue comes in contact with the puncture. 
Whether the lung disease of this pig was contracted from the feeding must be 
determined from additional cases. 
No. 392 died from swine plague, with a few doubtful hog cholera lesions and with 
hog cholera bacteria in the spleen. The remainder of the exposed animals had no 
swine plague lesions, but death was caused by acute hog cholera.* 
The history of this animal is instructive,as it was inoculated from a culture of 
swine plague bacteria, which operation did not protect it from taking the disease 
subsequently. January 25, 1887, injected into each thigh about 2° from a beef 
*The next case of swine plague in this pen died June 29, over two months after 
the death of No. 392. 
