318 DR. E. KLEIN. 



reagents, e.g. acetic acid, cliromate of potash, alcoliol, 

 chromic acid with or without sab?(>quciit staining in carmiiio 

 or hrematoxylin, but in the absolutely uninjiued bLi(Uh^r, /.e., 

 Avhilc tliis organ was being observed in the living (curarisrd) 

 animal. In a subsequent note ("Zur Kenntnis des Zellkcrns") 

 in ' Centralblatt f. medic. Wiss.,' 1877, No. 20, Flemming 

 states that he observed the same network in the nuclei of 

 various cells also hi the living and jyerfecthj uninjtircd larva 

 of Salamandra. 



In Strassburger's^ great work {' Uber Zellbildung und 

 Zelltheilung,' Jena 1875), we notice in developing cells of 

 PJiascolus multijlorus a network of fibrils radiating from 

 the nucleolus, permeating the interior of the luicleus in con- 

 nection with a similar network of the cell-substance. 



]Mayzel- met in the epithelium of the cornea of frog, rabbit 

 and cat, during regeneration, with large round nuclei, in 

 wliich he observed filamentous masses either in a convoluted 

 manner or radiating from a central point. Mayzel regarded 

 these forms as due to a particular stage of division, as de- 

 scribed by Biitschli and Strassburger. 



Eberth^ noticed similar nuclei in the epithelium of the 

 eornea and the endothelium of the membrana Dcscemeti 

 under normal and abnormal conditions, /.(?. nuclei containing 

 anastomosing filaments in their interior. Eberth also regards 

 them as peculiar forms in the development and division of 

 nuclei. 



Eimer"^ found in numerous nuclei that the granules of the 

 * granular zone' surrounding his ' hyaloid' are due to proto- 

 plasmic filaments, which permeate the interior of the nucleus 

 and anastomose with each other so as to form a network. 

 This network extends to the membrane of the nucleus, and 

 also sends radiating fibrils tlirougli the hyaloid into the 

 nucleolus. Such or similar is the condition in the nucleus 

 of ciliated epithelial cells of the palate of Salamandra 

 macidata, in those of cells lining the irmcr surface of the 

 tentacular wall of Aegineta, the sensory cells and the ecto- 

 derm-cells of Carmarina hastata and others. The network 

 of fibrils of the nucleus is in some instances also in connection 

 with fibrils and networks of such, belonging to the cell-sub- 

 stance itself. 



' For an excellent abstract see Mr. J. Priestley in this Journal, Vol. XVI, 

 p. 138, and Plate XII, figs. 1— G. 



•^ 'Centralbl. f. Medic. Wiss.,' N. 50, 1S75. 



^ "Uber Kern- und Zelltlicilunp-," ' Vircliow's Arcliiv,' 15d. 07. 



•* "Wcitcrc Nac'hrichtcn iiber den Pau des Zclkerncs," &c., 'Arcliiv f. 

 Mikrosk. Anatomic,' Bd. xiv, p. 01. See also " Notes and Memoranda " of 

 Ai)ril Number ot this Journal, 1S7S. 



