90 REVIEWS. 



acute miliary tuberculosis in man, based upon the examina- 

 tion of the lungs of seven children who died of this disease. 

 He found that in early cases the tubercles were due to 

 catarrhal pneumonia ; the alveoli being found distended with 

 a fibrinous material in which numerous lymphoid cells 

 (emigrated colourless corpuscles) were imbedded, the struc- 

 ture of the alveolar wall was barely discernible, and its 

 capillaries obliterated. In later stages the fibrinous exudation 

 which occupied the alveoli gradually disappears by absorption, 

 and becomes replaced by groups of cells which are mostly 

 derived from the alveolar epithelium, or by one large multi- 

 nuclear mass or giant-cell. The giant-cell is connected by 

 processes with a retiform tissue infiltrated with lymphoid 

 cells, which represents the alveolar septa. This is not true 

 adenoid tissue, but is regarded by Dr. Klein, in agreement 

 with Schlippel, as formed by cells derived from the giant-cells. 

 The giant-cell finally degenerates into a mass of debris, some- 

 times passing through a previous fibrous stage. Dr. Klein 

 considers that, in the lung, giant-cells are formed from the 

 alveolar epithelium, though he admits that it is possible that 

 they may arise (according to the observations of Ziegler) 

 from emigrated colourless blood-corpuscles. In still later 

 stages, when the above tubercles already show necrotic 

 changes, numerous blood-vessels are found surrounded by 

 perivascular cords, and spherical collections of adenoid tissue 

 are met with in the adventitia of the bronchi, so that the 

 various processes take place in man in inverted order as 

 compared with the artificial tubercle of guinea-pigs. 



The book is illustrated with six admirable double plates, 

 and is certainly among the most valuable of Dr. Klein's 

 numerous contributions to normal and pathological histology. 



The Histology and Histochemistry of Man. By Heinrich 



Frey, Professor of Medicine in Zurich. Translated from 



the fourth German edition by Arthur E, J. Barker. 



London, 1874. (Pp. 683 ; 604 woodcuts.) 



No working histologist who is acquainted with the German 



language needs any introduction to Professor Frey's manual. 



Avowedly a compilation, it is yet a very satisfactory and 



valuable compilation, and, especially for students' use, is 



perhaps the most useful text-book on the subject in any 



language. It is hardly necessary to say that it has gone 



through several editions, and as each successive issue has had 



to be brought up to the present day, as the phrase is, some 



parts present a curious patchwork of conflicting views, or 



