NOTES AND MEMORANDA. 181 



tnuch larger, perfectly bright, spherical or irregular-shaped, 

 whereas at the same time the filamentous appendix disappears. 

 These granules make their appearance all over prepara- 

 tions ; they are not limited to certain foci. The most of 

 them are to be found on those places in which plasma is still 

 unclosed. 



After the twelfth day, up to which time their number has 

 increased immensely, no material change can be made out, 

 even up to the twentieth day, except that some become a 

 little larger, brighter, and more sharply outlined. 



In preparations of the blood .of patients suffering from 

 different diseases (endocarditis, acute rheumatism, Addison's 

 disease, gout, jaundice, pneumonia, tuberculosis, variola, 

 puerperal peritonitis, septicaemia), the above-described cor- 

 puscles make their appearance only in an extremely limited 

 number. Consequently, a preparation of blood Avhich con- 

 tains only a few of those corpuscles is unavailable for a 

 diagnosis ; whereas a preparation that contains a great 

 number of them can be said to have been taken from a syphi- 

 litic patient. Biesiadecki succeeded in this respect, just as 

 Lostorfer, in being able to point out in a series of mixed 

 preparations, submitted to him and prepared in the above- 

 mentioned manner, which of them had been taken from 

 syphilitic patients, and which not; except in one prepara- 

 tion, in which Lostorfer's corpuscles were present abundantly, 

 and which was taken from a patient suffering from pustuia 

 maligna ; it could not be ascertained, however, whether this 

 patient did not suffer from syphilis. 



Biesiadecki shows that these corpuscles are not fat, not 

 sarcina, not granules of colourless corpuscles, and not fungi, 

 as Lostorfer was inclined to assume, but that they are 

 granules of precipitated paraglobulin ; for, a, if a current of 

 carbonic acid be allowed to pass through a preparation of 

 diluted serum (plasma? — Rej)^ of a dog, similar corpuscles to 

 those above described make their appearance ; on replacing 

 carbonic acid by oxygen they disappear; b, if through a 

 blood-preparation, in which numerous syphilis-corpuscles 

 have developed, a current of oxygen be allowed to pass, the 

 small ones disappear, whereas the larger ones diminish con- 

 siderably in size ; c. the syphilis-corpuscles do not dissolve 

 in either, but they dissolve almost entirely in a large quan- 

 tity of saline solution (one part of concentrated saline solution 

 in two parts of water). All these are properties which belong 

 to paraglobulin. 



In blood-preparations, therefore, which are kept in a moist 

 chamber, that is, in which, on the one hand, the plasma 



