ON THE PATHOLOGY OF SHEEP-POX. 233 
appearance. ‘These groups appear to correspond to 
those figured by Cohn as microspheera vaccine. 
In the same preparation after it had been kept at the 
temperature of incubation for 24 hours, the transparent masses 
referred to above (1), were found to have undergone the re- 
markable changes shown in fig. 2. 
Tine, As 
Under a high power it is seen that they consist of spherical 
granules of different sizes arranged in rows, each granule 
being united to its successor by pale transparent substance, 
so that the whole appears to be made up of a feltwork of 
delicate granular filaments, among which separate granules 
are seen here and there. In preparations kept for 48 hours 
the larger masses are seen to have broken up into smaller 
ones, in which the individual fibrils can be more easily traced, 
while the granules themselves have assumed characters which 
correspond to those of the micrococci (3), and pale spheroids 
(2) seen in the fresh lymph. This conversion of the granules 
contained in the masses into spheroids and micrococci, goes 
on for some days, so that these bodies multiply very consider- 
ably in the liquid. 
Examination of perfectly recent Lymph. 
A drop of lymph obtained on March 24th from a pustule 
of an animal that had been inoculated March 10th was ex- 
amined microscopically without dilution, and was found to 
contain, in addition to granular pus-corpuscles and coloured 
blood-corpuscles, numerous small highly refractive granules, 
either isolated or in couples, which exhibited molecular move- 
ment. After having been kept at 32°C. for 27 hours, it 
exhibited the following structures (fig. 3) in addition to 
those already mentioned :— 
1]. Pus-corpuscles, of which the substance has become 
swollen and transparent, each containing from two to 
six homogeneous slightly refractive spheroids. These 
1 The numbering of the paragraphs corresponds as before to that of the 
Fig. (3). 
