158 DR. E. KLEIN, 



Secondly, the cells are considerably shorter, their substance is a 

 close network of fibrils, hence their aspect is more granular than 

 in the former state ; their nucleus contains a uniform network 

 is less compressed, but not quite round, and is slightly more 

 removed from the membrana propria than in the former state ; 

 this second state is found only after prolonged secretion. In 

 both stages, however, the cell-substance presents more or less a 

 longitudinal striation owing to the network being arranged more 

 or less longitudinally. Unlike Ebstein, I have found in a 

 good many glands during digestion real mucous cells as 

 in the mucous and submaxillary glands, i.e., I have seen the 

 interfibrillar or interstitial substance staining with logwood like 

 mucin does, and for this reason I think that these cells are not 

 quite so removed from mucous secretion as Ebstein states. The 

 columnar epithelial cells lining the ducts of these glands and 

 covering the free surface of the mucosa are, during digestion, 

 loaded with mucin, as has been known to F. E. Schuitze, 

 Ebstein and Watney. In the dog I have never seen them other- 

 wise but open, and I agree therefore, with F. E. Schuitze and 

 Biedermann against Ebstein, who states that they are closed in 

 the state of hunger, and is therein confirmed, at any rate for the 

 pylorus of rabbit, by Watney (loc. cit,, p. 47 1).^ 



In my article on '' Stomach,^' in Stricker^s * Handbook,^ p. 

 543, 1 have stated that neither in the human stomach nor in that 

 of dog do I find such a definite boundary between the peptic 

 and the pyloric glands, as had been maintained by Henle, 

 Kolliker, Donders, Leydig and others, but that the unbranched 

 glands containing peptic cells merge into the branched glands of 

 the pylorus lined with simple columnar cells. These latter were 

 then always described as the mucous glands in contradistinction to 

 the peptic glands of the fundus. Rollett (loc. cit.) has con- 

 tradicted that assertion, inasmuch as he found always a sharp 

 contrast and boundary between the two kinds of glands. 

 Ebstein (loc. cit., p. 517), on the other hand, while agreeing 

 with Eollett that the mucous membrane of the regio pyloria 

 contains onl^ glands that are lined with columnar cells, and does 

 not contain any so-called peptic cells — i.e., cells corresponding 

 to the parietal cells of Heidenhain, finds in the stomach of dog 

 a small region, " intermediary zone," in which, between the so- 

 called mucous glands, one or two peptic gland tubes may be met 

 with. This zone is, according to Ebstein, about 1 — 1-5 centim. 

 broad, and lies just where the brownish mucous membrane of the 



1 I agree with Watney that tlie nuclei are in no stage of digestion so 

 round as represented by Ebstein, at any rate not over very large parts of the 

 stomach, although I think Watney goes too far in saying that they are 

 always discoid, i. e, congressed ; this, although true for specimens pre- 

 pared with chromic acid, is not applicable to spirit-specimens. 



