GLANDULAR EPITHELIUM AND DIVISION OK NUCLEI. 405 



with a sudden jerk the whole or part of their fat molecules 

 and continuing afterwards their ama?boid movement. The 

 above giant nuclei vary considerably in size^ the smallest 

 being 21 by 22 /u (0-021 by 0-022 mm.), the largest 126 by 

 129 |u (0-126 by 0-129 mm). 



Their shape is very various, some being spherical, others 

 oval or egg-shaped ; the largest examples are oval and 

 slightly compressed. This latter condition is ascertained in 

 vertical sections through the glands when the lining epithe- 

 lial cells and their nucleus present themselves in profile view. 



The intranuclear network^ contains fibrils of various 

 thickness, either uniform or possessed of irregular thicken- 

 ings, and larger or sa^aller trabeculae. Different parts of 

 one and the same nucleus vary greatly in this respect. The 

 intranuclear network presents itself in its best form in the 

 perfectly fresh and living nuclei, that is, in nuclei that on 

 the warm stage (in blood or humor aqueous) show the 

 amoiboid movement. Treated with reagents, the network is 

 less distinct. Sections obtained of tail hardened with 

 chromic acid or picric acid, or a mixture of picric acid and 

 osmic acid, and subsequently stained in carmine or hsema- 

 toxylin, show in some of the nuclei a distinct network, in 

 others it is not so easily perceived ; but even in the best 

 examples the network is incomparably less perfect and clear 

 than in the fresh state under the above conditions. 



The arrangement of the network varies very much; it is 

 either a more or ]ess uniform reticulum, or the fibres of the 

 peripheral part of the network are arranged in a transverse 

 manner, so as to give it the appearance of a " basket," or its 

 fibrils and trabeculag are more or less radiating towards a 

 central point or central line. Of great interest are those 

 forms which consist of two nuclei joined by a broader or 

 narrower neck through which the fibrils of the network of 

 one pass into that of the other. 



When the gland cells possess two nuclei these are either 

 completely separated or in the state just mentioned. The nuclei 

 with this latter quality are generally the smaller examples. 

 Some of the giant nuclei, both the smallest as well as the 

 largest, in fresh as well as in hardened specimens, are possessed 

 of several larger or smaller knob-like projections, whereby the 

 outline becomes notched and the nucleus looks as if lobed. 



In figures 2, 3, 4, 5, 6, and 7 I have represented several of 



' I purposely avoid the expression " framework" (geriiste) used by Mem- 

 miug, but use the term (intranuclear) network ; the former is bad, for the 

 simple reason that the network is the chief and living part of the nucleus ; 

 the term " framework " (geriiste) implies a passive stroma. 



VOL. XIX. NEW SER. J) D 



