CLARKE, ON STRIPED MUSCULAR FIBRE. 7 
month of October, my attention was directed to a recent 
paper on the development of striated muscular fibre by 
Deiters, of Bonn.* This author’s observations were made on 
the tissue formed during regeneration of the tail of the tad- 
pole. The conclusions at which he arrives are as follows: 
1. Striated muscular fibre results from the transforma- 
tion of a structure belonging to the class of connective 
tissues. 
2. This transformation proceeds directly from the con- 
nective-tissue-cells, which, however, preserve their spindle 
and stellate shapes. 
3. The essential nature of the process consists in this— 
that the cells deposit the striated substance on their outer 
cell-wall, so that it possesses the relation of an intercellular 
substance. 
4, This substance shows itself at first in the form of a 
simple, long, smooth, and frequently transversely striated 
band or border of condensed material (Verdickungssaum), 
which corresponds to our fibrilla, and increases by the con- 
tinual deposition of new layers on its outside. 
5. The deposition takes place mostly on one side, but may 
occur on other sides. 
6. During this process the cells multiply by a considerable 
increase in the number of the nuclei. At the same time 
the striated border increases in length, and may extend very 
far beyond the cell. 
7. The cells do not lie immediately behind one another, 
but either side by side or obliquely behind each other, 
somewhat in the fashion of tiles. 
8. The formative cells are connected with the connective- 
tissue-cells of the tendons. 
9. The sarcolemma is the last product of the developed 
primitive bundles; it is not cell-membrane. 
From some of these statements it is obvious that, as 
regards the manner in which the muscular fibres first make 
their appearance in the blastema, there is a general coinci- 
dence of this author’s views with those put forth by Savory, 
as well as with my own. ‘The chief points of difference are 
the followig :—Ist. That although, accordmg to Deiters, 
the muscular fibres are not formed directly by the coalesced 
substance of nucleated cells, as maintamed by Schwann and 
others, yet that nucleated cells are the real agents in their 
development. 2nd. That these “formative cells’ are not 
* ¢Beitrag zur Histologie der quergestreiften Muskeln,’ von Dr. Otto 
Deiters. Reichert’s u, Du Bois-Reymond’s ‘ Archiv,’ Heft iii und iy, 
