THE TRYPANOSOMA BRUCII. 461 



tains a very large number of amoeboid forms, a few plasmodia, 

 and a few adult forms. The liver, kidneys, and bone marrow 

 only contain adult forms in quantity corresponding with 

 those in the blood. The glands contain many amoeboid 

 forms, and a fair quantity of adult forms. The organism is 

 first found in the gland nearest to the point of inoculation, in 

 eighteen to twenty-four hours after inoculation. The cerebral 

 capillaries at the time of death are in great part blocked 

 with amoeboid forms (figs. 40 and 41). In the mouse the 

 appearances are quite similar, but the number in the blood 

 never reaches the number found in the rat. In the dog and 

 cat the spleen is enlarged and contains amoeboid and plas- 

 modial forms, but it is not so large relatively as that of the 

 rat. Their blood does not become infectious until the fourth 

 day after inoculation, and never contains such quantities of 

 the organisms as does rats' blood. The glands in both cat 

 and dog are always affected, as in the rat, and contain both 

 amoeboid and adult forms ; the bone marrow also contains 

 many adult and amoeboid forms. In the rabbit the organ- 

 isms are only found at irregular intervals in the blood, and 

 then only in very small numbers. The glands are not 

 enlarged at the time of death, which may be as long as three 

 months from the date of inoculation. The spleen is not 

 enlarged, and only contains a few amoeboid forms ; the bone 

 marrow is almost entirely free. In this animal the chief 

 obvious lesions are a swelling of the eyelids with a slowly 

 progressive panophthalmitis, and a soft oedema of the genitals. 

 These also occur, but less markedly, in the dog and cat. 

 It begins always as a plugging up of the lymphatics, 

 which contain numbers of the organisms, principally of the 

 amoeboid form, so the disease in these animals seems princi- 

 pally to affect the lymphatic system. The goat shows very 

 little sign, and the organism is not found abundantly in the 

 blood, but the animal gets oedema of the genitals, and the 

 eyes become somewhat opaque. It dies in about two months 

 after inoculation, with paralysis. The spleen is not enlarged ; 

 the nasal mucous membrane becomes swollen, and interferes 



