310 Prof. E. D. Smith on Caleulous Affections. 
In connection with this part of the subject would it not be 
a valuable, pathological fact to ascertain, whether females in 
general, and male children are more subject to one peculiar 
kind of calculus than to another; and whether this is like- 
wise the ae with regard to male adults, at different peri- 
ods of life ? 
It might also be an useful inquiry, what influence climate 
has in producing such a state of the system as favors the 
formation of calculous matter. We are told that such dis- 
eases are exceedingly rare, either in very hot or very cold 
countries ; and to discover whether the extremes of tem- 
perature prevent such alterations of the digestive powers, 
as take place in more temperate climates, would therefore 
be an interesting pasate fact. 
From all that has been now said, may it not be inferred 
tears ceavaee, oe uninterrupted mental pursuits, by 
confinement, even in active employments, toa close room 
&c.: a combination of two or more of these causes being 
sufficiently injurious, although one alone might not 
And if this influence be correct, the propriety of using rem- 
edies that act chemically upon ‘the fluids, while the othet 
pe indications are likewise attended to, is sufficiently evi- 
nt. 
Hoping that this imperfect essay will incite the inquirer 
after knowledge to investigate, for himself, the sources of in- 
formation as to this interesting subject, among such I wou 
take the liberty to mention the 22d, 23d, 24th, 25th, 30tb 
and 34th volumes of the London. Medical and Physical 
Journal, and Dr. Marcet’s treatise upon calculous disorders, 
observing however that of this last work I have seen only @ 
review, but that I entertain no doubt of its being oy most 
atisfactory eboeed has yet cy igi 
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