72 i'® B—t M .a c/) mmin r~ Wt X 



(Tvpts from tlio tunica projiria, destroviiia: cprtain })oiiits of the crypts walls, whioli 

 can actually be made out ; consequciitly the present assumption is disproved. 



In tlip tliird place and histly, I have mentioned in the foregoing pages tliat 

 tlie raucous memlirane is excessively dej^ressed at the points where the curious bodies 

 are found. The depression shows for each body the shape of a funnel, so that it 

 encloses tlie basal lialf of the body ; the underlying tissues, especially tlie tunica 

 propria and the submueosa, are strongly pressed, so as to be turned into compact 

 layers. When we follow tlie series of sections through a depression, we see that the 

 mucous epithelium forming the bottom of the depression is, in a certain extent, 

 dissolved. Furtliermore, tlie fibers of the tunica propria adjacent to the depressions 

 are also melted together, and the numerous parasitic cells are found Imbedded in 

 this molten mass. This part is the only point which is to be recognised as the 

 entrance of the parasites, as the following considerations will prove. 



Suppose that the parasitic cells arrive at the interior lumen of the coecum, 

 liaving been carried in by the food ingested; the cells sooner or later fasten them- 

 selves on the surface of the raucous membrane of the coecum. By the influence 

 of their parasitic life on this part, there is produced an abnormal body, as it seems 

 to me, in a simil;;r way as the gall-nut is producd on a plant leaf, to which gall- 

 wasps or gall-mites give their irritating stimuli, iu leading their parasitic life on it. 



The increasing irritation of the mucous membrane bv the parasites causes, as 

 it were, the abnormal body In question to be added in its bulk, so that it presses, 

 at last, strongly upon the coecal wall, until the wall has been depressed inlo a 

 funnel-shaped pit, embracing tlie basal half of the body. If this assumption Is 

 correct, the body in question may represent what was s])okeii of above as the curious 

 body, and it follows that the pit is nothing else than the above-mentioned finiuel- 

 shaped dejiression. 



Xext, the parasites migrate into the tissu(>s of tlie ccecal wall, destroying the 

 e])ithelial lining; in the first step, they come into view in the tunica propria and 

 turn, as above stated, the structure into amorphous masses, in which they are found 

 imbedded. I can not say with certainity, however, how this is brought about; but 

 there is little doubt in assuming that the changes are effected by the parasitism. 



The parasites not merely wander about within the tissue of the tunica propria, 

 but force their way, on one hand, into the submueosa, and on the other, into the 

 mucosa layer, under rapid multiplications. In the submueosa they do not give any 

 marked change to the structure at all. On the contrary, the mucous epithelium 



