474 ILLINOIS STATE ACADEMY OF SCIENCE 



before treatment, the white count was reported as 85,000 ; 

 on December 15, after treatment, it was 28,000. Also, 

 both spleen and liver had decreased in size. The lower 

 border of the spleen maintained about the same position, 

 but the npper border showed a marked retraction. The 

 patient grew cheerful and hojDeful of improvement. On 

 January 10, 1920, a second Radium treatment was given. 

 On January 6 the white count was reported as 33,000 ; on 

 January 15, after this treatment, it was 47,000. On 

 January 24 an X-Ray treatment was administered. 

 Later X-Ray treatments beyond the extension of this 

 study were made. The patient died in October, 1920, 

 making the total duration of the disease 2 years, 5 

 months. 



In the blood picture the most striking feature was, of 

 course, the large number of white corpuscles, and espe- 

 cially the presence of a large percentage of myelocytes 

 of the neutrophile variety. Anemia — decrease in the 

 number of red corpuscles, was also present. A large 

 number of nucleated red cells was found. Many of the 

 red cells, as well as the white, showed karyokinetic fig- 

 ures. Extruded nuclei, blood platelets, and fragmented 

 cells were prominent. Anisocytosis, Poikilocytosis, and 

 crenation were present in variable extent throughout the 

 period of observation. The hemoglobin was diminished 

 in approximate proportion to the red blood corpuscles, 

 and stood usually at 75%. A number of rare pathological 

 forms were noticed. One megakaryocyte was discovered. 



The progress of the disease can best be observed by 

 means of the accompanying charts and graphs. Chart 

 I shows the complete observation (with exception of 

 certain white counts in the earlier part of the treatment 

 for which slides were not available. These counts are 

 taken from clinical reports and included in the graphs). 

 For each day for which blood slides were available a 

 differential count was made of 200 white cells. The tabu- 

 lation shows the percentage of Polymorphonuclear neu- 

 trophiles. Polymorphonuclear eosinophiles. Polymorpho- 

 nuclear basophiles, L^Tnphocytes, Mononuclear leuco- 

 cytes, neutrophilic Myelocytes, eosinophilic Myelocytes, 

 and basophilic Myelocytes, respectively. During the 



