368 REPORT OF THE COMMISSIONER OF AGRICULTURE. 



it beyoud question, Dr. Law inocnlated a second y>)^ frora vinis taken 

 from the iirst. This inoculation was successful. While followed by but 

 a sli^i'bt elevation of temperature, all the other characteristic symptoms 

 of the disease were well marked. Tlie post-mortem examinatiou was 

 made on the twelfth day after the iiidculatiou, when the usual lesions of 

 the plague were found. The red and black blotches on the skin were 

 extensive, the ears blue, the intestines extensively congested, with en- 

 larged follicles in the c;ecum and colon, and blood extravasations and 

 ulcers in the rectum. Purp/le discoloration s and i)etechiio were numer- 

 ous on the bver, kidneys, and heart, and linally the lymphatic gland.s 

 in general were in part congested of a deep red, and in part pigmented 

 as the result of a previous congestion. 



Another successful inoculation of a pig was made from virus from an 

 infected lamb. The pig was inoculated from material taken from the 

 swelling in the axilla (near the seat of inoculation) of the lamb. The 

 inoculation produced fever, with the general malaise, moping, ijeevish 

 grunt, inapetence, and the cutaneous blotches of swine plague. The 

 animal was killed on the eleventh day after inoculation, when the au- 

 topsy was at once made. The skin showed a number of red and purple 

 blotches, aiul was covered with tiio black unctuous exudation so fre- 

 quently obser\ ed in this disease. The bowels contained iiatches of con- 

 gestion, the coecum and colon were enlarged, and the follicles and the 

 rectum were ulcerated. The liver, kidneys, and heart contained the 

 usual purple blotches. Finally, the lymphatic glands in the abdom.ea 

 were enlarged and congested of a deep red or black, and those in the 

 chest and guttural region were darkly pigmented. Tliis was regarded 

 as a most unequivocal case, and fully confirmed the position heretofore 

 taken by l)r. Law, viz., that the virus of swine plague may be trans- 

 mitted through the sheep and conveyed back to the pig with active and 

 deadly eiicct. 



This experiment was followed by the inoculation of a pig with virus 

 fro7n infected rat and lamb, and also inoculations with virus from in- 

 fected ))ig, rat, and lamb. By reference to the first experiment it will 

 be seen that while the i)jg showed but little elevation of temperature, 

 there was a pnri>le cutaneous eruption of the skin on the fifth day and 

 enlarged glands on tlie twelfth, v^iien it was inoculated with bloody mu- 

 cus from the anus of the infected lamb. After this the symptoms be- 

 came rar.cii more severe, and wlien killed, twenty-two days after, the an- 

 imal showed unmistakable lesions of the disease. 



The next subiect was that of a healthy female Suffolk pig. Tins was 

 inoculated with albumen which had been charged with a drop of blood 

 containing bacteria drawn from an infected pig. Forfifteendays nothing 

 more was shown than a few jrarple spots and patches on the rump, tail, 

 and hocks. The subject was then reinoculated with the congested intes- 

 ti lie of the rat which had died two days after inoculation. The intestine 

 had been frozen over night. For thirteen days more the same equivocal 

 symptoms continued, A third inoculation was now practiced, this time 

 with bloody mucus from the anus of the lamb. Twenty-two days after 

 this inoculation the pig Avas sacriticed, but beyond some ])igmentationof 

 the lymphatic glands presented no distinct lesions that could be held 

 characteristic of the spcciiic fever. 



On February 5, 1871), Dr. Law inoculated a rat with virulent matter that 

 had been j)rescrved lor seventy-eight days closely packed in dry wheat 

 brdn. The rodent was preser\ ed for thirteen days, when it was kdled 

 and immecbately dissected. The symptoms during life and the lesions^ 

 found after doatli woro so rlosdyin 1c('(»]iing with thosr' of swiiv^ r-l'i'/no. 



