578 PROCEEDINGS OF SECTION G2. 



is limited to the pyloric opening. The submucosa is often oedema- 

 tous, especially that of the folds. The small intestines, especially 

 the duodenum, may show congestion. Generally the submucosa is 

 somewhat oedematous, and very often the lumen, empty of ingesta, 

 contains more or less serous effusion, which has all the characters 

 of the effusions elsewhere. In one instance this effusion was 

 observed to possess a coagulated central core, so tenacious as 

 to permit several inches to be pulled through an incision of 

 the bowel wall. The large intestines are generally normal. 

 The lungs are usually normal, but may be very oedematous. The 

 heart may show sub- epicar dial and sub-endocardial haemorrhages. 

 No odour is to be detected throughout the cadaver, provided 

 the post-mortem examination is made soon after death. 



Attempts to transmit the disease by feeding with from two 

 to five cc. of virulent cultures have proved negative. 



Cattle. — Only one animal has been inoculated — a three-months* 

 old calf in good condition — 0.5 cc. virulent broth culture being 

 injected subcutaneously. Death resulted 54 hours after inocula- 

 tion. Post-mortem examination disclosed extensive infiltration 

 of the subcutaneous tissues with oedema, pleural and pericardial 

 effusions, congestion and haemorrhagic patches of theabomasum 

 mucosa, oedema of the lungs, etc. (See Appendix.) 



Gtiineapigs. — Guineapigs inoculated with small doses, 0.1 to 

 0.25 cc, of young pure sub-cultures generally succumb in less than 

 20 hours. The post-mortem appearances are very similar to those 

 of the sheep, there being intense oedematous infiltration, with 

 some haemorrhage and gas formation in the muscles of the whole limb, 

 and subcutaneous tissues of the abdomen. Effusions into the 

 serous cavities are common, and vary in amount and character. 

 The liver frequently shows small areas of necrosis in its congested 

 tissue. Spleen often pulpy and at times enlarged. Kidneys 

 usually congested. The stomach may show slight congestion of 

 the mucosa, as may the small intestines. Very frequently the small 

 intestines are distended by more or less clear effusion into the lumen. 



Rabbits. — Both tame and wild rabbits are very susceptible ; 

 0.10 to 0.25 cc. of pure young subculture invariably causes death 

 in from 16 to 24 hours, generally under 20 hours. Beyond an ex- 

 tensive subcutaneous oedema, clear and semi-gelatinous, there is 

 little pathological change to be observed. 



It should be here noted that rabbits immune to a certain strain 

 of malignant oedema bacillus proved on subsequent inoculation 

 with this bacillus to be equally susceptible with other rabbits not 

 previously inoculated. 



Pigeons inoculated with 0.1 to 0.25 cc. broth culture die in less 

 than 24 hours, the muscles of the inoculated breast being swollen 

 and oedematous. Generally there is no other pathological change, 

 though in one instance a small quantity of sero-sanguineous effusion 

 was present in the abdomen. 



