8-J Original Vaccine Pock Imtiiution. 



the anfivariolodng process ', and the state so produced may 

 be named the nittivariolous state. 



C. It appears from instances which are registered, that 

 variolous and vaccine matter may be circumstanced so that 

 their respective appropriate agencies upon a given human 

 constitution shall be conteniporarv ; i. e. conmience their 

 action at the same time. In such instances, a very much 

 smaller proportion of cases ot" severe constitutional disorder 

 occur than in the singlv inoculated small pox ; and al- 

 though eruptions most frequently appear, they are most 

 usually fewer in nun)bcr, of shorter duration, and defective 

 as variolous ones in the respects of size, in not suppurathig, 

 and often not containing infectious matter. Oftentimes 

 there are only mere pimples, and sometimes no eruption 

 at all. 



7. The vaccine matter has in many instances been 

 known to exert its constitutional agencv at various periods, 

 whilst the antivariolatiiig process is i^oing on bv variolous 

 inoculation ; in which circumstances there was a much 

 smaller proportion of exemptions from eruptions; and aU 

 though there were some instances of small pox regular and 

 perfect, in all their stages of pimple, vesicle, and pustule, 

 yet there was a very large proportion of slio;lu and defective 

 variola:, as just stated in proposition fi ; and if in certain 

 cases the small pox did not seem to be mitigated and rcn-t 

 dered defective, there was no indication tiiat thev were in 

 any case rendered more severe. In general, the degree of 

 the variolous disease was directly as the length of time be- 

 tween the inoculation of variolous matter and the subse- 

 quent inoculation of vaccine matter, within the limits of 

 space of time in which successive insertions of the two 

 morbific matters can act in conjunction during the anti- 

 variolativg process. 



8. The variolous matter also has been made to exert it>> 

 constitutional agency at various periods of the antivariolat- 

 ing process excited bv vaccine inoculation, and then there 

 was a less proportion of eruptive cases : the eruptions were 

 in general small, fewer in number, of shorter duration, and 

 often more defective, in not only having no purulent matter, 

 but even no lymph, than in the set of cases last mentioned 

 (proposition /.) : of course the constitutional illness occur- 

 red in a smaller proportion than in the preceding cases. 



The principal different circumstances in which the two 

 morbific matters were placed to exert then- energies were the 

 following : 



1st. The insertion of vaccine and variolous matter into 

 the same punctured or abraded part?. 



2d. The 



