(h'igmal Vaccine Pock Institution. S3 



5d. The insertion of vaccine and variolous matter into 

 the vaccine pimple or vesicle already formed. 



3d. 'Ihe insertion ot" vaccine matter into the variolous 

 pimple or vesicle already formed. 



4th. The inoculation of variolous and vaccine matter on 

 ■dislinct pants, hut at the same time. 



5th. The inoculation of variolous matter at certain deter- 

 minate times, after vaccine inoculation, in distinct .parts, 

 but on the same person. 



6th. The inoculation of vaccine matter at certain deter- 

 minate times after variolous i-uoculation, in distinct parts, 

 but in the ^ame person. 



7th. The inoculation of the two morbillc matters con-* 

 tiguously, yet so that either as the vaccine and variolous 

 grew to a certain size, the matters intermingled, or they 

 were mingled by perfai'atiug the vesicles to xeiader them 

 confluent. 



Remarks. 



1. The Inoculation with the matter of fhe vaccine and 

 variolous vesicles existing in the same persons, excited 

 simple regular vaccina and variola in distinct persons. 



2. The inoculation with the matter of the vesicle pro- 

 iluced bv the insertion of both vaccine and variolous matter 

 commonlv produced the vaccina without eruptions : some- 

 times, however, they did occur, but the matter of these 

 eruptions did not in ^wo or three trials excite either vaccina 

 or variola. From the irregularity of the pock of tiie inocu- 

 lated part and the eruptions, it seemed reasoiiable to con- 

 clude that perhaps such matter consisted of both vaccine 

 and variolous, which was capable of propagating the two 

 diseases in some instances conjointly. 'Ihe experiments 

 on this point, however, are considered to be inadequate to 

 answer the question. 



3. The trials of the late Dr. Woodville and the reporter, 

 by inoculatiijg with mixed variolous and vaccine matter, 

 proved formerly that no hybrid disease could be formed : 

 but their former conclusion does not now seem just, that 

 in some instances the variolous disease, and in others the 

 vaccine alone, was excited by such matter ; nor had thev 

 then the least notion of cotemporarv agency of the tw(j> 

 morbific matters both locally and constitutionally. 



4. There will now be no difficulty to explain the in- 

 stances of breaking out of the natural small pox eruptions 

 between the 8th and Idth day in the vaccine inoculation, 

 without seemingly disturbing the progress of the vaccine 



F 3 pock. 



