Vaa'ine Inst'iiutlon. £S7 



three^ four, or five days, there will be seen a red spot 

 like a small gnat-bite ; in six or seven days, a small vesicle 

 will appear f in nine days, a circular vesicle (improperly 

 called a pustule) will be found as large as a pea, or from 

 about two-ttnlhs to four-tenths of an inch in diameter, 

 usually surrounded by a red areola. By the eleventh day 

 the vesicle begins to scab or grow dry, and turn black in 

 the middle, aiid the areola becomes more extensive. By 

 the fifteenth day, but often later, the pock becomes a mere 

 scab, circular, 'prominent, well defined, of a blackish or 

 mahogany colour, adhering firmly ; but the areola disap- 

 pears. Unless it be separated by violence the scab does not 

 fall oft', in general, sooner than the twentieth day. It then 

 leaves a cicatrix permanent for life. 



VI. If the eruption or pimple excited by inoculation has 

 not the characters and does not pass through the stages in 

 the course above stated (V), although sometimes anoma- 

 lous, this cow-pock may render the constitution unsus- 

 ceptible of the small-pox,' yet it cannot be depended upon. 

 In such cases, the inoculation should be re-instituted ; for, 

 if the vaccina cannot be again excited, the unsusceptibilily 

 desired will have been produced : but if a further proof be 

 wanted, recourse must be had to inoculation w ith the va- 

 riolous matter. 



VII. In many cases, no constitutional affection or fever 

 can be perceived : when it occurs, it is almost always on 

 the ninth and tenth days ; but provided the pock exhibit the 

 distinctive characters of the cow- pock, even without areola, 

 with the usual course of its stages, the susceptibility of the 

 small-pox will be as effectually destroyed as if there had been 

 considerable febrile affection, and extensive areola. 



VIII. If erythema, like erysipelas, extend over the arm, 

 with suelling, pain, &c., it has always subsided in a few 

 days of itself, only avoiding irritating applications, or at 

 most on using sedatives. 



IX. Eruptions sometimes occur, but they require no par- 

 ticular treatment. 



X. The sinall-pox may break out at any period within 

 twelve days of inoculation for the cow-pock. If they ap- 

 pear earlier than the sixth or seventh, the vaccina is cut off 

 in its progress ; if they appear later, the vaccina goes for- 

 ward in its usual course. 



XI. The medical treatment which may be required from 

 unusual "or supenening complaints, being analogous to that 

 iivthe small-pox, must be accordingly. 



^ XII. Mca- 



