Vaccine Inoctilalhn. 185 



I was In queft of, and that, in the courfe of two days, the 

 puftiiles would unfold thenifelves. At this vifit which I. 

 made to the cows, there was prefent a dealer in the Grifons 

 cows, who fullv confirmed the truth of thefe aflertions. He 

 alfo added, that in his countrv he had feen the cows afflicted 

 with a fimilar eruption on their dugs, and to remove the in- 

 crultations it was common to anoint them with boiled oil 

 ufed for varnifli ; and that by this means they fell oft in the 

 courfe of two or three days. Early next morning I went 

 again to fee the cows, examined ihcm anew, and found on 

 one of them four red fpots already tumid and raifcd into puf- 

 tules ; three of thefe were fprcad over the nipples, and the 

 fourth lay in the middle of the dugs. The other cow had 

 fix puftules ; two on the nipples, and the reft fcattered abo\e 

 them. Thefe were hrger than thofe of the (iril cow, and 

 around them appeared a flight red circle. Apparently thefe 

 puflules occafioned much pain to the cowsj tor, on my ap- 

 proaching to examine them more minutely, they would 

 fcarcely permit me to touch them for one moment. Al- 

 though the puftules were already large and prominent, they 

 did not yet appear to me fufficiently mature to yield the matter 

 I wanted. As the cows were that day to «r;o forward on their 

 way to Milan, I found myfelf under the nceelTitv of follow- 

 ing them to their firft halting-place, in order to examine 

 them again next dav. I walked out at an early hour to 

 the meadow where they were at paflure; I examined the 

 puftulc-s, which appeared to me to be now arrived at maturi- 

 ty. They were lucid, and of a pale red colour, with a brown 

 fpot in the midd'ie more deprefl'ed ; and I thought this a fa- 

 vourable moment to eolle6l the matter, which, through the 

 afliltance of the hcrdfmen, I was eafily enabled lo do by re- 

 peatedly foaking a thread in it. Although I law no reafon 

 to doubt that this was the true cow-pox, yet, this being the 

 firft time I had ever feen it, I began to fi;fpe6t that the puf- 

 tules niight be of that kind which Jenner calls the fpurmis 

 cow-pox : I determined, therefoie, to decide the matter by 

 experiment. A confiderable mmibtr of experiments, all 

 uniform in their fymptoms and progrefs, and alwavs con- 

 ftant in their refults, put the matter bevond doubt, and gave 

 me full eonvii-tion that this was the true cow-pox. Such 

 and fo many are the obflacles to be overcome on the intro- 

 duction of any innovation, however falutary, that 1 for fome 

 time delpaired of being abl«' to induce any one to fubmit to 

 inoculation with the matter I had collei^ted. In fine, after 

 many fruillefs perfualions, I fueceeded in my delign : the 



fucecfs 



