Vaccine Inoculation. 93 



fever, depreffion of fpirits, and a pale countenance. In a f(p\y 

 inftances, in which the inoculated part attained to a due 

 degree of maturity, and where a fwelling of the axillary 

 glands was obferved, no figns of any illnefs exifted, at leaft 

 ho fymptoms could be obferved which proved the infe6lion 

 to have afted upon the whole fyftem. Thefe I fliall re-Ino- 

 culate, Should the refult be as before, would it be fair to 

 fuppofe them fecured againft fmall-pox infeftion ? 



" The moft of our phyficians here exclaim againft the vac- 

 cine inoculation ; and their only weak and almoft refuted 

 arcirtnent is — Are people thus fecured for all their lifetime 

 againft the fmall-pox ? Neverthelefs I have the fatisfaftioa 

 to fee a partiality for it difplayed by the greater part of the 

 public ; and I have already inoculated many noblemen's 

 children, as well as thofe of other very refpeflable inha- 

 bitants of Hanover ; and, without doubt, I fhall always have 

 fubjetls fufficient for continuing this inoculation. 



" On the ninth, tenth, or eleventh day, when the inocu- 

 lated puftule is filled with lymph, and the furrounding in- 

 flammation is complete, I then ufually open it, colled the 

 lymph on cotton thread, and immediately lay fome more 

 thread upon it, which is removed the following day: all 

 thefe ferve for future inoculations. After this period I have 

 hitherto defifted to repeat colle6ling more matter from fuch 

 a puftule, but wifli to know how long it might be conti- 

 mied. 



" I (hall efteem it a great favour if you will lay thefe re- 

 fults and queftions before Dr. Pearfon, and beg he will have 

 the goodnefs to anfwer them. 



*' In Langenhagen, a village near Hanover, I have ino- 

 culated the clergyman's children along with four others ; 

 which induced many farmers and peafants to have their 

 children alfo inoculated. 



" From Halle, Halberftadt, and many other places, I have 

 received applications for vaccine matter; which proves that 

 the continent has many adherents to the vaccine inocula- 

 tion as well as England. 



" Dr.Ballhorn, an intimate and long acquaintance of mine, 

 ^fliftcd me iij moft of thefe operations, in order that he rnight 



vifit 



